Slc13a3 solute carrier family 13 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc13a3provided by RGD
Official Full Name: solute carrier family 13 member 3provided by RGD
Primary source: RGD:628786
See related: Ensembl:ENSRNOG00000019118 AllianceGenome:RGD:628786
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NaC3; Nadc3; SDCT2
Summary: Enables carboxylic acid transmembrane transporter activity. Involved in aspartate transmembrane transport; citrate transport; and succinate transmembrane transport. Located in membrane. Is integral component of membrane. Orthologous to human SLC13A3 (solute carrier family 13 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1513.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (174561174..174623893, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (154141878..154204604, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (162084336..162147398, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NaDC3 promotes cellular senescence probably by inhibiting NAD(+)-dependent SIRT1.
Title: High-affinity Na(+)-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

stSG607484 (e-PCR)
- UniSTS:446993

RH130357 (e-PCR)
- UniSTS:213641

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-ketoglutarate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables citrate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables citrate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dicarboxylic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dicarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glutathione transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glutathione transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity sodium:dicarboxylate symporter activity	IEA Inferred from Electronic Annotation more info
enables high-affinity sodium:dicarboxylate symporter activity	ISO Inferred from Sequence Orthology more info
enables organic acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:dicarboxylate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:dicarboxylate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:dicarboxylate symporter activity	ISO Inferred from Sequence Orthology more info
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables succinate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in alpha-ketoglutarate transport	IEA Inferred from Electronic Annotation more info
involved_in aspartate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in citrate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in citrate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dicarboxylic acid transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dicarboxylic acid transport	ISO Inferred from Sequence Orthology more info
involved_in dicarboxylic acid transport	ISO Inferred from Sequence Orthology more info
involved_in glutathione transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glutathione transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in succinate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in succinate transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Na(+)/dicarboxylate cotransporter 3

Names: Na(+)-coupled carboxylate transporter 3; naDC-3; rNaDC3; sodium-dependent high-affinity dicarboxylate transporter 2; sodium-dependent high-affinity dicarboxylate transporter 3; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022866.2 → NP_074057.2 Na(+)/dicarboxylate cotransporter 3

See identical proteins and their annotated locations for NP_074057.2

Status: PROVISIONAL

Source sequence(s)

BC129094

UniProtKB/Swiss-Prot

Q9Z0Z5

UniProtKB/TrEMBL

A2VD10

Related

ENSRNOP00000025843.4, ENSRNOT00000025843.6

Conserved Domains (2) summary

cd01115
Location:42 → 556

SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...

TIGR00785
Location:31 → 565

dass; anion transporter