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    Mrm3 mitochondrial rRNA methyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360569, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrm3provided by RGD
    Official Full Name
    mitochondrial rRNA methyltransferase 3provided by RGD
    Primary source
    RGD:1309077
    See related
    Ensembl:ENSRNOG00000037238 AllianceGenome:RGD:1309077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnmtl1; RGD1309077
    Summary
    Predicted to enable identical protein binding activity and rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA 2'-O-methylation. Predicted to be located in mitochondrion. Orthologous to human MRM3 (mitochondrial rRNA methyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 67.4), Muscle (RPKM 63.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrm3 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (61594155..61623659)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (61095920..61125421)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (64398308..64406193)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene diazepam binding inhibitor-like 5 Neighboring gene glyoxalase domain containing 4 Neighboring gene nucleoredoxin Neighboring gene uncharacterized LOC120095143 Neighboring gene translocase of inner mitochondrial membrane 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA). Lee KW, et al. J Biol Chem, 2014 Sep 5. PMID 25074936, Free PMC Article
    2. Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid. Lee KW, et al. J Biol Chem, 2013 Oct 25. PMID 24036117, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA (guanosine-2'-O-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA 2'-O-methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rRNA methyltransferase 3, mitochondrial
    Names
    RNA methyltransferase like 1
    RNA methyltransferase-like protein 1
    NP_001101752.1
    XP_017452868.1
    XP_038942255.1
    XP_038942256.1
    XP_038942257.1
    XP_038942258.1
    XP_038942259.1
    XP_038942260.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108282.1 → NP_001101752.1  rRNA methyltransferase 3, mitochondrial

      See identical proteins and their annotated locations for NP_001101752.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HGV3, D3ZQG0
      Related
      ENSRNOP00000053117.3, ENSRNOT00000056278.4
      Conserved Domains (2) summary
      smart00967
      Location:125 → 191
      SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding
      cd18106
      Location:210 → 400
      SpoU-like_RNMTL1; SAM-dependent rRNA methylase related to RNMTL1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      61594155..61623659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086330.2 → XP_038942258.1  rRNA methyltransferase 3, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl38912
      Location:117 → 254
      SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

    2. XM_039086327.2 → XP_038942255.1  rRNA methyltransferase 3, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl38912
      Location:117 → 254
      SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

    3. XM_039086328.2 → XP_038942256.1  rRNA methyltransferase 3, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl38912
      Location:117 → 243
      SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

    4. XM_039086329.2 → XP_038942257.1  rRNA methyltransferase 3, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl38912
      Location:117 → 243
      SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

    5. XM_039086332.2 → XP_038942260.1  rRNA methyltransferase 3, mitochondrial isoform X6

      Conserved Domains (1) summary
      cl38912
      Location:117 → 243
      SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

    6. XM_039086331.2 → XP_038942259.1  rRNA methyltransferase 3, mitochondrial isoform X5

      Conserved Domains (1) summary
      cl38912
      Location:117 → 243
      SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

    7. XM_017597379.3 → XP_017452868.1  rRNA methyltransferase 3, mitochondrial isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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