Tctn1 tectonic family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tctn1provided by RGD
Official Full Name: tectonic family member 1provided by RGD
Primary source: RGD:1566266
See related: Ensembl:ENSRNOG00000028523 AllianceGenome:RGD:1566266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566266
Summary: Predicted to be involved in cilium assembly and protein localization to ciliary transition zone. Predicted to act upstream of or within in utero embryonic development; nervous system development; and regulation of smoothened signaling pathway. Predicted to be located in ciliary transition zone; extracellular space; and membrane. Predicted to be part of MKS complex. Human ortholog(s) of this gene implicated in Joubert syndrome 13. Orthologous to human TCTN1 (tectonic family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 127.8), Adrenal (RPKM 90.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (39970554..40003727)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (34309795..34347190)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (39790948..39828215)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH140698 (e-PCR)
- UniSTS:222765

BF403268 (e-PCR)
- UniSTS:246370

RH131127 (e-PCR)
- UniSTS:214410

RH130165 (e-PCR)
- UniSTS:213452

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system interneuron axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral neural tube patterning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube formation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to ciliary transition zone	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to ciliary transition zone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic motor neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MKS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MKS complex	ISO Inferred from Sequence Orthology more info
located_in ciliary transition zone	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tectonic-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401130.1 → NP_001388059.1 tectonic-1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

39970554..40003727

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598330.3 → XP_017453819.1 tectonic-1 isoform X1

UniProtKB/TrEMBL

D4A3L5

Related

ENSRNOP00000035012.4

RNA

XR_010056385.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001177613.1: Suppressed sequence

Description

NM_001177613.1: This RefSeq was removed because currently there is insufficient support for the transcript.