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    Marchf3 membrane associated ring-CH-type finger 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364878, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Marchf3provided by RGD
    Official Full Name
    membrane associated ring-CH-type finger 3provided by RGD
    Primary source
    RGD:1359308
    See related
    Ensembl:ENSRNOG00000023013 AllianceGenome:RGD:1359308
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    March3
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in endosome and lysosome. Orthologous to human MARCHF3 (membrane associated ring-CH-type finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 50.6), Lung (RPKM 35.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Marchf3 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (52435292..52587321, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (50237218..50389343, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (51844980..51998017, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483028 Neighboring gene uncharacterized LOC120098251 Neighboring gene lamin B1 Neighboring gene small ribosomal subunit protein uS3-like Neighboring gene uncharacterized LOC120098149 Neighboring gene similar to human chromosome 5 open reading frame 63 Neighboring gene mitochondrial ribosomal protein L30, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II. Fukuda H, et al. J Biochem, 2006 Jan. PMID 16428329
    2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. Bartee E, et al. J Virol, 2004 Feb. PMID 14722266, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC94648

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF3
    Names
    E3 ubiquitin-protein ligase MARCH3
    MARCH-III
    RING-type E3 ubiquitin transferase MARCH3
    RING-type E3 ubiquitin transferase MARCHF3
    membrane-associated RING finger protein 3
    membrane-associated RING-CH protein III
    membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
    NP_001007760.1
    XP_006254811.1
    XP_063133562.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007759.1 → NP_001007760.1  E3 ubiquitin-protein ligase MARCHF3

      See identical proteins and their annotated locations for NP_001007760.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083738
      UniProtKB/Swiss-Prot
      Q33E96, Q5XIE5
      UniProtKB/TrEMBL
      A0A8L2QGG7
      Related
      ENSRNOP00000030051.4, ENSRNOT00000039177.5
      Conserved Domains (1) summary
      cd16699
      Location:70 → 120
      RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      52435292..52587321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254749.5 → XP_006254811.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

      See identical proteins and their annotated locations for XP_006254811.1

      UniProtKB/Swiss-Prot
      Q33E96, Q5XIE5
      UniProtKB/TrEMBL
      A0A8L2QGG7
      Related
      ENSRNOP00000071176.1
      Conserved Domains (1) summary
      cd16699
      Location:70 → 120
      RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

    2. XM_063277492.1 → XP_063133562.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

      UniProtKB/Swiss-Prot
      Q33E96, Q5XIE5
      UniProtKB/TrEMBL
      A0A8L2QGG7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIE5.1 GenPept UniProtKB/Swiss-Prot:Q5XIE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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