Slc6a13 solute carrier family 6 member 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc6a13provided by RGD
Official Full Name: solute carrier family 6 member 13provided by RGD
Primary source: RGD:620788
See related: Ensembl:ENSRNOG00000012876 AllianceGenome:RGD:620788
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GAT-2
Summary: Enables neurotransmitter binding activity and organic anion transmembrane transporter activity. Involved in neurotransmitter transport and organic anion transport. Located in plasma membrane. Orthologous to human SLC6A13 (solute carrier family 6 member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 388.0), Kidney (RPKM 115.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (156211381..156248491)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (154539246..154577784)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (153874942..153912185)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that GAT2 is responsible for taurine transport from the circulating blood to hepatocytes predominantly in the periportal region.
Title: Involvement of γ-aminobutyric acid transporter 2 in the hepatic uptake of taurine in rats.
GAT2 makes a major contribution to the sinusoidal GAA uptake by periportal hepatocytes, thus regulating creatine biosynthesis in the liver
Title: γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.
RGat2-mediated d(3)-GBB uptake was Na(+) and Cl(-) dependent.
Title: Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2.
large number of GAT2-immunoreactive structures that surrounded neurons within each ganglion of the myenteric plexus.
Title: Neuronal and glial localization of GABA transporter immunoreactivity in the myenteric plexus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables creatine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables gamma-aminobutyric acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables gamma-aminobutyric acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IEA Inferred from Electronic Annotation more info
enables gamma-aminobutyric acid:sodium:chloride symporter activity	ISO Inferred from Sequence Orthology more info
enables monocarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables taurine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables taurine:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables taurine:sodium symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in creatine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid import	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid transport	IEA Inferred from Electronic Annotation more info
involved_in monocarboxylic acid transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in taurine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in taurine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in taurine transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium- and chloride-dependent GABA transporter 2

Names: solute carrier family 6 (neurotransmitter transporter), member 13; solute carrier family 6 (neurotransmitter transporter, GABA), member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133623.1 → NP_598307.1 sodium- and chloride-dependent GABA transporter 2

See identical proteins and their annotated locations for NP_598307.1

Status: PROVISIONAL

Source sequence(s)

M95762

UniProtKB/Swiss-Prot

P31646

UniProtKB/TrEMBL

A6ILC5, R9PXV0

Related

ENSRNOP00000018083.3, ENSRNOT00000018083.4

Conserved Domains (1) summary

cl00456
Location:32 → 575

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

156211381..156248491

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237218.5 → XP_006237280.2 sodium- and chloride-dependent GABA transporter 2 isoform X1

UniProtKB/TrEMBL

R9PXV0

Conserved Domains (1) summary

cl00456
Location:32 → 581

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006237220.5 → XP_006237282.2 sodium- and chloride-dependent GABA transporter 2 isoform X2

UniProtKB/Swiss-Prot

P31646

UniProtKB/TrEMBL

A6ILC5, R9PXV0

Conserved Domains (1) summary

cl00456
Location:32 → 575

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006237219.4 → XP_006237281.2 sodium- and chloride-dependent GABA transporter 2 isoform X1

UniProtKB/TrEMBL

R9PXV0

Conserved Domains (1) summary

cl00456
Location:32 → 581

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006237221.4 → XP_006237283.2 sodium- and chloride-dependent GABA transporter 2 isoform X2

UniProtKB/Swiss-Prot

P31646

UniProtKB/TrEMBL

A6ILC5, R9PXV0

Conserved Domains (1) summary

cl00456
Location:32 → 575

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006237223.5 → XP_006237285.2 sodium- and chloride-dependent GABA transporter 2 isoform X5

UniProtKB/TrEMBL

R9PXV0

Conserved Domains (1) summary

cl00456
Location:1 → 456

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006237222.5 → XP_006237284.2 sodium- and chloride-dependent GABA transporter 2 isoform X3

UniProtKB/TrEMBL

R9PXV0

Related

ENSRNOP00000071638.2

Conserved Domains (1) summary

cl00456
Location:25 → 537

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063285457.1 → XP_063141527.1 sodium- and chloride-dependent GABA transporter 2 isoform X4

UniProtKB/TrEMBL

A0A0G2K0Z3, R9PXV0
XM_039106983.2 → XP_038962911.1 sodium- and chloride-dependent GABA transporter 2 isoform X6

Conserved Domains (1) summary

cl00456
Location:1 → 296

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain