Acsf3 acyl-CoA synthetase family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acsf3provided by RGD
Official Full Name: acyl-CoA synthetase family member 3provided by RGD
Primary source: RGD:1586037
See related: Ensembl:ENSRNOG00000015077 AllianceGenome:RGD:1586037
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable malonyl-CoA synthetase activity and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid biosynthetic process and malonate catabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 185.6), Adrenal (RPKM 149.9) and 9 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (67743660..67784109)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (50835116..50875557)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (55594801..55635312)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables acid-thiol ligase activity	ISO Inferred from Sequence Orthology more info
enables malonyl-CoA synthetase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables very long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables very long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in malonate catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

Preferred Names: acyl-CoA synthetase family member 3, mitochondrial; malonate--CoA ligase ACSF3, mitochondrial

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_574249.9 → XP_574249.5 malonate--CoA ligase ACSF3, mitochondrial isoform X1

UniProtKB/TrEMBL

A6IZU1, D3ZUX7

Related

ENSRNOP00000020313.4

Conserved Domains (1) summary

cd05941
Location:55 → 569

MCS; Malonyl-CoA synthetase (MCS)
XM_008772665.4 → XP_008770887.2 malonate--CoA ligase ACSF3, mitochondrial isoform X2