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    Sprn shadow of prion protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 541462, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sprnprovided by RGD
    Official Full Name
    shadow of prion proteinprovided by RGD
    Primary source
    RGD:1561845
    See related
    Ensembl:ENSRNOG00000067971 AllianceGenome:RGD:1561845
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in several cellular components, including cytosol; nucleolus; and vesicle. Predicted to be active in nucleus. Orthologous to human SPRN (shadow of prion protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 307.1), Brain (RPKM 215.0) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sprn in Genome Data Viewer
    Location:
    1q41
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (204373936..204378074, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194944602..194948448, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (212619817..212623686, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene polyamine oxidase Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene olfactory receptor family 6 subfamily A member E1 Neighboring gene olfactory receptor family 6 subfamily F member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The highly conserved, N-terminal (RXXX)8 motif of mouse Shadoo mediates nuclear accumulation. Tóth E, et al. Biochim Biophys Acta, 2013 May. PMID 23360978
    2. Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency. Daude N, et al. Proc Natl Acad Sci U S A, 2012 Jun 5. PMID 22619325, Free PMC Article
    3. Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. Premzl M, et al. Gene, 2003 Sep 18. PMID 14527721
    4. Evolution of vertebrate genes related to prion and Shadoo proteins--clues from comparative genomic analysis. Premzl M, et al. Mol Biol Evol, 2004 Dec. PMID 15342797
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    shadow of prion protein
    Names
    Shadoo
    protein shadoo
    shadow of prion protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031845.1 → NP_001027015.1  shadow of prion protein precursor

      See identical proteins and their annotated locations for NP_001027015.1

      Status: PROVISIONAL

      Source sequence(s)
      BN000520
      UniProtKB/Swiss-Prot
      Q5BIV7
      UniProtKB/TrEMBL
      A6HXH7
      Conserved Domains (1) summary
      pfam14999
      Location:38 → 147
      Shadoo; Shadow of prion protein, neuroprotective

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      204373936..204378074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271934.1 → XP_063128004.1  shadow of prion protein isoform X1

      UniProtKB/TrEMBL
      A6HXH6

    2. XM_006230573.5 → XP_006230635.1  shadow of prion protein isoform X2

      See identical proteins and their annotated locations for XP_006230635.1

      UniProtKB/Swiss-Prot
      Q5BIV7
      UniProtKB/TrEMBL
      A6HXH7
      Related
      ENSRNOP00000094166.1
      Conserved Domains (1) summary
      pfam14999
      Location:38 → 147
      Shadoo; Shadow of prion protein, neuroprotective
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BIV7.1 GenPept UniProtKB/Swiss-Prot:Q5BIV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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