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    Alp7 Alkaline phosphatase 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37538, updated on 10-May-2024

    Summary

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    Official Symbol
    Alp7provided by FlyBase
    Official Full Name
    Alkaline phosphatase 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0034710
    Locus tag
    Dmel_CG3292
    See related
    AllianceGenome:FB:FBgn0034710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3292; Dmel\CG3292
    Summary
    Predicted to enable alkaline phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPL (alkaline phosphatase, biomineralization associated); ALPG (alkaline phosphatase, germ cell); and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Alp7 in Genome Data Viewer
    Location:
    58D1-58D1; 2-99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22203694..22205593, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18091199..18093098, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Secreted Wg-interacting molecule Neighboring gene ncRNA Neighboring gene antisense RNA:CR45376 Neighboring gene Alkaline phosphatase 2 Neighboring gene Alkaline phosphatase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Implications of Membrane Binding by the Fe-S Cluster-Containing N-Terminal Domain in the Drosophila Mitochondrial Replicative DNA Helicase. So M, et al. Front Genet, 2021. PMID 34950192, Free PMC Article
    2. A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. Huet F, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12096187, Free PMC Article
    3. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540
    4. Mapping Dmef2-binding regulatory modules by using a ChIP-enriched in silico targets approach. Junion G, et al. Proc Natl Acad Sci U S A, 2005 Dec 20. PMID 16339902, Free PMC Article
    5. Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association. Hamilton PT, et al. mBio, 2015 Sep 15. PMID 26374124, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alkaline phosphatase 7
    Names
    Alp7-PA
    CG3292-PA
    NP_611653.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22203694..22205593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137809.2 → NP_611653.1  alkaline phosphatase 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W275
      Related
      FBpp0071696
      Conserved Domains (1) summary
      cl23718
      Location:94 → 533
      ALP_like; alkaline phosphatases and sulfatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W275 Q9W275

    Gene LinkOut

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