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    disp dispatched [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44274, updated on 10-May-2024

    Summary

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    Official Symbol
    dispprovided by FlyBase
    Official Full Name
    dispatchedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029088
    Locus tag
    Dmel_CG2019
    See related
    AllianceGenome:FB:FBgn0029088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0146227.1; CG2019; Disp; Dmel\CG2019
    Summary
    Involved in several processes, including patched ligand maturation; pole cell migration; and regionalization. Located in cytoneme. Is expressed in adult head; imaginal disc; organism; and wing disc. Orthologous to several human genes including DISP1 (dispatched RND transporter family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See disp in Genome Data Viewer
    Location:
    83C5-83C5; 3-47.5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5849697..5856311, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1675419..1682033, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46133 Neighboring gene ECSIT Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structure of the Hedgehog release protein Dispatched. Cannac F, et al. Sci Adv, 2020 Apr. PMID 32494603, Free PMC Article
    2. A fixation method to preserve cultured cell cytonemes facilitates mechanistic interrogation of morphogen transport. Bodeen WJ, et al. Development, 2017 Oct 1. PMID 28827391, Free PMC Article
    3. Cholesterylation: a tail of hedgehog. Ciepla P, et al. Biochem Soc Trans, 2015 Apr. PMID 25849927
    4. Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila. Zhao Y, et al. Nat Commun, 2022 Dec 19. PMID 36535958, Free PMC Article
    5. Wingful, an extracellular feedback inhibitor of Wingless. Gerlitz O, et al. Genes Dev, 2002 May 1. PMID 12000788, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Dispatched could be involved in the regulation of vesicular trafficking necessary for basolateral release of Hh, Dlp, and Ihog.
      Title: Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.
    2. dispatched plays a role in hedgehog body patterning, as demonstrated in transgenic flies
      Title: Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5852013-5851958 mobile_element_type = transposon:FB{}5719

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in germ cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in patched ligand maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in patched ligand maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dispatched
    Names
    CG2019-PA
    disp-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5849697..5856311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079995.3 → NP_524734.2  dispatched [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524734.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B6IDI9, Q5U173, Q8SY40, Q9U477, Q9VNJ5
      Related
      FBpp0078314
      Conserved Domains (3) summary
      pfam02460
      Location:444 → 1111
      Patched; Patched family
      cl00454
      Location:964 → 1109
      TM_PBP1_branched-chain-AA_like; Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of ...
      cl21543
      Location:457 → 627
      MMPL; MMPL family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNJ5.1 Q9VNJ5

    Gene LinkOut

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