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    Phactr2 phosphatase and actin regulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 215789, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Phactr2provided by MGI
    Official Full Name
    phosphatase and actin regulator 2provided by MGI
    Primary source
    MGI:MGI:2446138
    See related
    Ensembl:ENSMUSG00000062866 AllianceGenome:MGI:2446138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Is expressed in several structures, including body cavity or lining; brain; genitourinary system; respiratory system; and vertebral axis musculature. Human ortholog(s) of this gene implicated in Parkinson's disease and multiple sclerosis. Orthologous to human PHACTR2 (phosphatase and actin regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 5.6), limb E14.5 (RPKM 4.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A2; 10 4.72 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13083461..13350266, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13207717..13474525, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene zinc finger, C2HC-type containing 1B Neighboring gene STARR-seq mESC enhancer starr_25812 Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene predicted gene, 46211 Neighboring gene STARR-seq mESC enhancer starr_25813 Neighboring gene STARR-seq mESC enhancer starr_25814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene fucosidase, alpha-L- 2, plasma Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene adenosine deaminase, tRNA-specific 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Different expression patterns of Phactr family members in normal and injured mouse brain. Kim JY, et al. Neuroscience, 2012 Sep 27. PMID 22766235
    2. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Allen PB, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15107502, Free PMC Article
    3. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. Wilson CH, et al. EMBO J, 2012 May 30. PMID 22510880, Free PMC Article
    4. ZFP57 dictates allelic expression switch of target imprinted genes. Jiang W, et al. Proc Natl Acad Sci U S A, 2021 Feb 2. PMID 33500348, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonistrated that the mRNA expression of phactr2 was progressively increased in the injury penumbra.
      Title: Different expression patterns of Phactr family members in normal and injured mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase and actin regulator 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033257.5 → NP_001028429.1  phosphatase and actin regulator 2 isoform D

      See identical proteins and their annotated locations for NP_001028429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (D) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon and lacks an in-frame exon, compared to variant A. The encoded isoform (D) has a distinct N-terminus and is shorter than isoform A.
      Source sequence(s)
      AK142930, AL713985, CJ060660
      Consensus CDS
      CCDS35846.1
      UniProtKB/TrEMBL
      A3KGD2, B1AVP0, Q3UQ19
      Related
      ENSMUSP00000101182.3, ENSMUST00000105543.9
      Conserved Domains (2) summary
      smart00707
      Location:445 → 469
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:72 → 94
      RPEL; RPEL repeat

    2. NM_001195065.1 → NP_001181994.1  phosphatase and actin regulator 2 isoform A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (A).
      Source sequence(s)
      AC156949, AL713985
      Consensus CDS
      CCDS87962.1
      UniProtKB/TrEMBL
      F7D4H5, Q91VK6
      Related
      ENSMUSP00000101184.6, ENSMUST00000105545.12
      Conserved Domains (1) summary
      smart00707
      Location:508 → 532
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    3. NM_001195066.1 → NP_001181995.1  phosphatase and actin regulator 2 isoform B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (B) has a distinct N-terminus and is shorter than isoform A.
      Source sequence(s)
      AK139466, AL713985
      Consensus CDS
      CCDS87961.1
      UniProtKB/TrEMBL
      B1AVN9, B1AVP0
      Related
      ENSMUSP00000078637.7, ENSMUST00000079698.7
      Conserved Domains (2) summary
      smart00707
      Location:438 → 462
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:61 → 83
      RPEL; RPEL repeat

    4. NM_001195096.2 → NP_001182025.1  phosphatase and actin regulator 2 isoform C

      See identical proteins and their annotated locations for NP_001182025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform A.
      Source sequence(s)
      AL713985, BE650511, CJ060660
      UniProtKB/TrEMBL
      A1L3S9, B1AVP0
      Conserved Domains (2) summary
      smart00707
      Location:449 → 473
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:72 → 94
      RPEL; RPEL repeat

    5. NM_001359294.1 → NP_001346223.1  phosphatase and actin regulator 2 isoform E

      Status: VALIDATED

      Source sequence(s)
      AL713985, BE650511, CJ060660
      Conserved Domains (2) summary
      smart00707
      Location:396 → 420
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:72 → 94
      RPEL; RPEL repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      13083461..13350266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512673.5 → XP_006512736.1  phosphatase and actin regulator 2 isoform X8

      UniProtKB/TrEMBL
      B1AVP0
      Conserved Domains (2) summary
      smart00707
      Location:588 → 612
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:132 → 153
      RPEL; RPEL repeat

    2. XM_006512676.3 → XP_006512739.1  phosphatase and actin regulator 2 isoform X13

      UniProtKB/TrEMBL
      Q91VK6
      Conserved Domains (1) summary
      smart00707
      Location:424 → 448
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    3. XM_006512675.3 → XP_006512738.1  phosphatase and actin regulator 2 isoform X10

      UniProtKB/TrEMBL
      Q91VK6
      Conserved Domains (2) summary
      smart00707
      Location:451 → 475
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:132 → 153
      RPEL; RPEL repeat

    4. XM_006512674.3 → XP_006512737.1  phosphatase and actin regulator 2 isoform X9

      UniProtKB/TrEMBL
      Q91VK6
      Conserved Domains (2) summary
      smart00707
      Location:455 → 479
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:132 → 153
      RPEL; RPEL repeat

    5. XM_006512671.3 → XP_006512734.1  phosphatase and actin regulator 2 isoform X6

      UniProtKB/TrEMBL
      Q91VK6
      Conserved Domains (2) summary
      smart00707
      Location:504 → 528
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:132 → 153
      RPEL; RPEL repeat

    6. XM_006512667.3 → XP_006512730.1  phosphatase and actin regulator 2 isoform X3

      UniProtKB/TrEMBL
      Q91VK6
      Conserved Domains (2) summary
      smart00707
      Location:570 → 594
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:132 → 153
      RPEL; RPEL repeat

    7. XM_006512665.3 → XP_006512728.1  phosphatase and actin regulator 2 isoform X1

      UniProtKB/TrEMBL
      B1AVP0
      Conserved Domains (2) summary
      smart00707
      Location:584 → 608
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:132 → 153
      RPEL; RPEL repeat

    8. XM_006512677.4 → XP_006512740.1  phosphatase and actin regulator 2 isoform X15

      Conserved Domains (2) summary
      smart00707
      Location:381 → 405
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:62 → 83
      RPEL; RPEL repeat

    9. XM_036155728.1 → XP_036011621.1  phosphatase and actin regulator 2 isoform X12

      UniProtKB/TrEMBL
      B1AVP0
      Conserved Domains (2) summary
      smart00707
      Location:434 → 458
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:62 → 83
      RPEL; RPEL repeat

    10. XM_006512670.4 → XP_006512733.1  phosphatase and actin regulator 2 isoform X5

      UniProtKB/TrEMBL
      B1AVP0
      Related
      ENSMUSP00000101185.2, ENSMUST00000105546.8
      Conserved Domains (2) summary
      smart00707
      Location:518 → 542
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:62 → 83
      RPEL; RPEL repeat

    11. XM_036155729.1 → XP_036011622.1  phosphatase and actin regulator 2 isoform X14

      Conserved Domains (2) summary
      smart00707
      Location:392 → 416
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:73 → 94
      RPEL; RPEL repeat

    12. XM_036155730.1 → XP_036011623.1  phosphatase and actin regulator 2 isoform X16

      Conserved Domains (1) summary
      smart00707
      Location:365 → 389
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

    13. XM_006512669.5 → XP_006512732.1  phosphatase and actin regulator 2 isoform X4

      UniProtKB/TrEMBL
      B1AVP0
      Conserved Domains (2) summary
      smart00707
      Location:529 → 553
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:73 → 94
      RPEL; RPEL repeat

    14. XM_030245000.1 → XP_030100860.1  phosphatase and actin regulator 2 isoform X11

      UniProtKB/TrEMBL
      Q91VK6
      Conserved Domains (2) summary
      smart00707
      Location:455 → 479
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:132 → 153
      RPEL; RPEL repeat

    15. XM_006512672.1 → XP_006512735.1  phosphatase and actin regulator 2 isoform X7

      UniProtKB/TrEMBL
      Q91VK6
      Conserved Domains (2) summary
      smart00707
      Location:504 → 528
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:132 → 153
      RPEL; RPEL repeat

    16. XM_006512666.1 → XP_006512729.1  phosphatase and actin regulator 2 isoform X2

      UniProtKB/TrEMBL
      B1AVP0
      Conserved Domains (2) summary
      smart00707
      Location:584 → 608
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:132 → 153
      RPEL; RPEL repeat
    Nucleotide Protein Strain
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