Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppargc1bprovided by MGI
Official Full Name: peroxisome proliferative activated receptor, gamma, coactivator 1 betaprovided by MGI
Primary source: MGI:MGI:2444934
See related: Ensembl:ENSMUSG00000033871 AllianceGenome:MGI:2444934
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Perc; PGC-1beta; 4631412G21Rik; PPARGC-1-beta; PGC-1beta/ERRL1
Summary: Predicted to enable AF-2 domain binding activity; estrogen receptor binding activity; and nuclear receptor coactivator activity. Involved in several processes, including bone trabecula formation; positive regulation of phosphate metabolic process; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in brown fat; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 4.4), colon adult (RPKM 3.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 34.41 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (61424516..61533846, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (61291445..61400756, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dancr-BRG1 regulates Nfatc1 transcription and Pgc1beta-dependent metabolic shifts in osteoclastogenesis.
Title: Dancr-BRG1 regulates Nfatc1 transcription and Pgc1β-dependent metabolic shifts in osteoclastogenesis.
PGC-1beta modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds.
Title: PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds.
Adipose tissue-specific ablation of PGC-1beta impairs thermogenesis in brown fat.
Title: Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat.
FOXO1 suppresses PGC-1beta gene expression in skeletal muscles.
Title: FOXO1 suppresses PGC-1β gene expression in skeletal muscles.
Hepcidin-induced reduction in iron content and PGC-1beta expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis.
Title: Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis.
PGC-1beta-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse.
Title: PGC-1β-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse.
miR-378 and its host gene Ppargc1beta exhibit independent expression in mouse skeletal muscle.
Title: miR-378 and its host gene Ppargc1β exhibit independent expression in mouse skeletal muscle.
PGC-1beta Induces Susceptibility To Acetaminophen-Driven Acute Liver Failure.
Title: PGC-1β Induces Susceptibility To Acetaminophen-Driven Acute Liver Failure.
A novel long noncoding RNA PGC1beta-OT1 regulates adipocyte and osteoblast differentiation through antagonizing miR-148a-3p.
Title: A novel long noncoding RNA PGC1β-OT1 regulates adipocyte and osteoblast differentiation through antagonizing miR-148a-3p.
LXRalpha selectively activates transcription of miR-378 and inhibits expression of Ppargc1beta, which synergistically impairs fatty acid oxidation (FAO). In addition to lipogenesis, impaired FAO by miR-378 contributes to LXRalpha-induced hepatosteatosis
Title: LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1β Expression.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppargc1b (e-PCR), detects polymorphism
- UniSTS:479199

NoName (e-PCR)
- UniSTS:237820

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AF-2 domain binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of alkaline phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of mediator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisome proliferator-activated receptor gamma coactivator 1-beta

Names: ERR ligand 1; PPAR gamma coactivator-1beta protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364996.1 → NP_001351925.1 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2

Status: VALIDATED

Source sequence(s)

AC116595, AC121903

Consensus CDS

CCDS89250.1

UniProtKB/TrEMBL

B2RWT8

Related

ENSMUSP00000069431.6, ENSMUST00000063307.6

Conserved Domains (2) summary

cd12356
Location:907 → 986

RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins

cl28087
Location:178 → 443

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_133249.3 → NP_573512.1 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1

See identical proteins and their annotated locations for NP_573512.1

Status: VALIDATED

Source sequence(s)

AC116595, AC121903

Consensus CDS

CCDS29284.1

UniProtKB/Swiss-Prot

Q8C1C0, Q8VHJ7

UniProtKB/TrEMBL

B2RWT8

Related

ENSMUSP00000074771.7, ENSMUST00000075299.13

Conserved Domains (1) summary

cd12356
Location:891 → 970

RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

61424516..61533846 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525698.4 → XP_006525761.1 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1

UniProtKB/TrEMBL

B2RWT8

Conserved Domains (2) summary

PRK10263
Location:194 → 459

PRK10263; DNA translocase FtsK; Provisional

cd12356
Location:923 → 1002

RRM_PPARGC1B; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) and similar proteins