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    ADAM12 ADAM metallopeptidase domain 12 [ Homo sapiens (human) ]

    Gene ID: 8038, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ADAM12provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 12provided by HGNC
    Primary source
    HGNC:HGNC:190
    See related
    Ensembl:ENSG00000148848 MIM:602714; AllianceGenome:HGNC:190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1
    Summary
    This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in placenta (RPKM 63.0), gall bladder (RPKM 5.5) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADAM12 in Genome Data Viewer
    Location:
    10q26.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (126012391..126388477, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (126894888..127270982, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (127700960..128077046, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2929 Neighboring gene FANK1 antisense RNA 1 Neighboring gene G protein subunit gamma 10 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127731483-127732140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127737867-127738367 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:127763214-127764413 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:127823747-127824946 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:127836493-127836992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127845814-127846314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127846315-127846815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127850913-127851413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127863169-127863692 Neighboring gene RNA, 5S ribosomal pseudogene 328 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:127889000-127889180 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:127935743-127936942 Neighboring gene secretion associated Ras related GTPase 1A pseudogene 2 Neighboring gene uncharacterized LOC112267914 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:128113684-128114883 Neighboring gene long intergenic non-protein coding RNA 601 Neighboring gene uncharacterized LOC728158 Neighboring gene chromosome 10 open reading frame 90

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis. Yang S, et al. J Orthop Surg Res, 2023 Mar 1. PMID 36855121, Free PMC Article
    2. ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway. Xu J, et al. J Transl Med, 2023 Jan 30. PMID 36717944, Free PMC Article
    3. Expression of ADAM12 in Gastric Cancer and its Relation to Tumor Cell Behavior and Prognosis. Chung MW, et al. In Vivo, 2022 Sep-Oct. PMID 36099146, Free PMC Article
    4. Proteomics and Biochemical Analyses of Secreted Proteins Revealed a Novel Mechanism by Which ADAM12S Regulates the Migration of Gastric Cancer Cells. Chang Z, et al. J Proteome Res, 2022 Sep 2. PMID 35926154
    5. ADAM12 is an independent predictor of poor prognosis in liver cancer. Du S, et al. Sci Rep, 2022 Apr 22. PMID 35459884, Free PMC Article

    See all (223) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-135b-5p targets ADAM12 to suppress invasion and accelerate trophoblast apoptosis in preeclampsia.
      Title: MiR-135b-5p targets ADAM12 to suppress invasion and accelerate trophoblast apoptosis in preeclampsia.
    2. Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study.
      Title: Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study.
    3. ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy.
      Title: ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy.
    4. ADAM12 promotes the resistance of lung adenocarcinoma cells to EGFR-TKI and regulates the immune microenvironment by activating PI3K/Akt/mTOR and RAS signaling pathways.
      Title: ADAM12 promotes the resistance of lung adenocarcinoma cells to EGFR-TKI and regulates the immune microenvironment by activating PI3K/Akt/mTOR and RAS signaling pathways.
    5. ADAM Metallopeptidase Domain 12 Facilitates Colorectal Cancer Progression by Inhibiting Hippo Signaling Pathway Activity.
      Title: ADAM Metallopeptidase Domain 12 Facilitates Colorectal Cancer Progression by Inhibiting Hippo Signaling Pathway Activity.
    6. ADAM12 promotes gemcitabine resistance by activating EGFR signaling pathway and induces EMT in bladder cancer.
      Title: ADAM12 promotes gemcitabine resistance by activating EGFR signaling pathway and induces EMT in bladder cancer.
    7. The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis.
      Title: The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis.
    8. ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway.
      Title: ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway.
    9. Expression of ADAM12 in Gastric Cancer and its Relation to Tumor Cell Behavior and Prognosis.
      Title: Expression of ADAM12 in Gastric Cancer and its Relation to Tumor Cell Behavior and Prognosis.
    10. Proteomics and Biochemical Analyses of Secreted Proteins Revealed a Novel Mechanism by Which ADAM12S Regulates the Migration of Gastric Cancer Cells.
      Title: Proteomics and Biochemical Analyses of Secreted Proteins Revealed a Novel Mechanism by Which ADAM12S Regulates the Migration of Gastric Cancer Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (161)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study of endometrial cancer in E2C2.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31066

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myoblast fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 12
    Names
    meltrin-alpha
    metalloprotease-disintegrin 12 transmembrane

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029050.1 RefSeqGene

      Range
      5082..381168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001288973.2 → NP_001275902.1  disintegrin and metalloproteinase domain-containing protein 12 isoform 3 preproprotein

      See identical proteins and their annotated locations for NP_001275902.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3, also known as ADAM12-La) is shorter than isoform 1.
      Source sequence(s)
      AC063963, AK055628, KF444157
      Consensus CDS
      CCDS91373.1
      UniProtKB/TrEMBL
      Q5JRP2, U5NE98
      Related
      ENSP00000391268.2, ENST00000448723.2
      Conserved Domains (5) summary
      smart00050
      Location:436 → 504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:507 → 649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:211 → 411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:211 → 413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:60 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    2. NM_001288974.2 → NP_001275903.1  disintegrin and metalloproteinase domain-containing protein 12 isoform 4 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, lacks multiple 3' coding exons, and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AY358878, BC060804, CB960379, T91975
      UniProtKB/TrEMBL
      A8K6G4
      Conserved Domains (5) summary
      smart00050
      Location:436 → 504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:507 → 649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:211 → 411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:211 → 413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:60 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    3. NM_001288975.2 → NP_001275904.1  disintegrin and metalloproteinase domain-containing protein 12 isoform 5 preproprotein

      See identical proteins and their annotated locations for NP_001275904.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, lacks multiple 3' coding exons, and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK291629, AY358878, BC060804, CB960379, DA863951, T91975
      UniProtKB/TrEMBL
      A8K6G4
      Conserved Domains (5) summary
      smart00050
      Location:436 → 504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:507 → 649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:211 → 411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:211 → 413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:60 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    4. NM_003474.6 → NP_003465.3  disintegrin and metalloproteinase domain-containing protein 12 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_003465.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as ADAM12-Lb).
      Source sequence(s)
      AC063963, AF023476, AK055628, BC060804, DA027173, DR004947
      Consensus CDS
      CCDS7653.1
      UniProtKB/Swiss-Prot
      O43184, O60470, Q5JRP0, Q5JRP1, Q6P9E3, Q6UWB0
      Related
      ENSP00000357668.4, ENST00000368679.8
      Conserved Domains (5) summary
      smart00050
      Location:439 → 507
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:510 → 652
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:214 → 414
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:214 → 416
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:60 → 161
      Pep_M12B_propep; Reprolysin family propeptide

    5. NM_021641.5 → NP_067673.2  disintegrin and metalloproteinase domain-containing protein 12 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_067673.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as ADAM12-S) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF023476, AK291629, AY358878, BC060804, DR004947, T91975
      Consensus CDS
      CCDS7654.1
      UniProtKB/TrEMBL
      A8K6G4
      Related
      ENSP00000357665.4, ENST00000368676.8
      Conserved Domains (5) summary
      smart00050
      Location:439 → 507
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:510 → 652
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:214 → 414
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:214 → 416
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:60 → 161
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      126012391..126388477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016706.2 → XP_016872195.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X1

    2. XM_024448210.1 → XP_024303978.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X2

      Conserved Domains (3) summary
      smart00050
      Location:2 → 61
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:64 → 206
      ACR; ADAM Cysteine-Rich Domain
      cl26464
      Location:308 → 459
      Atrophin-1; Atrophin-1 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      126894888..127270982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366836.1 → XP_054222811.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X3

    2. XM_054366837.1 → XP_054222812.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X1

    3. XM_054366838.1 → XP_054222813.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43184.3 GenPept UniProtKB/Swiss-Prot:O43184

    Gene LinkOut

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