Il2rb interleukin 2 receptor subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il2rbprovided by RGD
Official Full Name: interleukin 2 receptor subunit betaprovided by RGD
Primary source: RGD:2896
See related: Ensembl:ENSRNOG00000048636 AllianceGenome:RGD:2896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IL2RBC
Summary: Enables interleukin-2 binding activity and interleukin-2 receptor activity. Involved in cytokine-mediated signaling pathway and natural killer cell activation. Located in cell surface. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 63; myasthenia gravis; and visceral leishmaniasis. Orthologous to human IL2RB (interleukin 2 receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 154.6), Lung (RPKM 92.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111913828..111928537, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110033341..110048054, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119701338..119716238, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH133980 (e-PCR)
- UniSTS:217262

Il2rb (e-PCR), detects polymorphism
- UniSTS:143559

RH94534 (e-PCR)
- UniSTS:119782

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-15 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-15 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-15 receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables interleukin-2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-2 binding	IEA Inferred from Electronic Annotation more info
enables interleukin-2 binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables interleukin-2 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-2 binding	ISS Inferred from Sequence or Structural Similarity more info
enables interleukin-2 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-2 receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to interleukin-2 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-2 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-2 receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-15-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-15-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-2-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-2-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: interleukin-2 receptor subunit beta

Names: IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; P70-75; high affinity IL-2 receptor subunit beta; interleukin 2 receptor, beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013195.2 → NP_037327.2 interleukin-2 receptor subunit beta precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P26896

UniProtKB/TrEMBL

A0A0G2KA53

Related

ENSRNOP00000075262.1, ENSRNOT00000077438.2

Conserved Domains (2) summary

cd00063
Location:135 → 232

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18707
Location:32 → 123

IL2RB_N1; Interleukin-2 receptor subunit beta N-terminal domain 1