Ppig peptidylprolyl isomerase G [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppigprovided by RGD
Official Full Name: peptidylprolyl isomerase Gprovided by RGD
Primary source: RGD:620315
See related: Ensembl:ENSRNOG00000007673 AllianceGenome:RGD:620315
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Located in nuclear matrix. Orthologous to human PPIG (peptidylprolyl isomerase G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 93.5), Thymus (RPKM 87.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (74891846..74923010)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (54484023..54512929)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (55959756..55990040)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH144287 (e-PCR)
- UniSTS:233532

RH136420 (e-PCR)
- UniSTS:210410

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclosporin A binding	IEA Inferred from Electronic Annotation more info
enables cyclosporin A binding	ISO Inferred from Sequence Orthology more info
enables cyclosporin A binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein peptidyl-prolyl isomerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase G

Names: PPIase G; cyclophilin G; matrin cyclophilin (matrin-cyp); matrin-cyp; peptidyl-prolyl isomerase G; rotamase G

NP_113981.2

EC 5.2.1.8

XP_006234386.1

EC 5.2.1.8

XP_006234387.1

EC 5.2.1.8

XP_006234388.1

EC 5.2.1.8

XP_006234389.1

EC 5.2.1.8

XP_006234390.1

EC 5.2.1.8

XP_006234392.1

EC 5.2.1.8

XP_006234393.1

EC 5.2.1.8

XP_006234395.1

EC 5.2.1.8

XP_006234396.1

EC 5.2.1.8

XP_006234397.1

EC 5.2.1.8

XP_017447552.1

EC 5.2.1.8

XP_017447553.1

EC 5.2.1.8

XP_038961873.1

EC 5.2.1.8

XP_063140727.1

EC 5.2.1.8

XP_063140728.1

EC 5.2.1.8

XP_063140730.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031793.2 → NP_113981.2 peptidyl-prolyl cis-trans isomerase G

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Related

ENSRNOP00000010216.5, ENSRNOT00000010216.7

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

74891846..74923010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234335.5 → XP_006234397.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234397.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_063284658.1 → XP_063140728.1 peptidyl-prolyl cis-trans isomerase G isoform X1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9
XM_006234328.5 → XP_006234390.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234390.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_006234331.5 → XP_006234393.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234393.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_017592064.3 → XP_017447553.1 peptidyl-prolyl cis-trans isomerase G isoform X1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_006234326.5 → XP_006234388.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234388.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_006234324.5 → XP_006234386.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234386.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_017592063.3 → XP_017447552.1 peptidyl-prolyl cis-trans isomerase G isoform X1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_006234327.5 → XP_006234389.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234389.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_006234333.5 → XP_006234395.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234395.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_039105945.2 → XP_038961873.1 peptidyl-prolyl cis-trans isomerase G isoform X1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_006234325.4 → XP_006234387.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234387.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_063284657.1 → XP_063140727.1 peptidyl-prolyl cis-trans isomerase G isoform X1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9
XM_006234330.4 → XP_006234392.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234392.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_006234334.4 → XP_006234396.1 peptidyl-prolyl cis-trans isomerase G isoform X1

See identical proteins and their annotated locations for XP_006234396.1

UniProtKB/Swiss-Prot

O55035, Q5U346

UniProtKB/TrEMBL

A6HM13, G3V6Y9

Conserved Domains (1) summary

cl00197
Location:8 → 175

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_063284660.1 → XP_063140730.1 peptidyl-prolyl cis-trans isomerase G isoform X2

UniProtKB/Swiss-Prot

O55035, Q5U346