P2rx6 purinergic receptor P2X 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P2rx6provided by RGD
Official Full Name: purinergic receptor P2X 6provided by RGD
Primary source: RGD:3243
See related: Ensembl:ENSRNOG00000001873 AllianceGenome:RGD:3243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2x6; P2rxl1; Rnap2x6
Summary: Enables extracellularly ATP-gated cation channel activity. Predicted to be involved in cation transmembrane transport; cell surface receptor signaling pathway; and response to ATP. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic specialization membrane. Orthologous to human P2RX6 (purinergic receptor P2X 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 54.0), Lung (RPKM 24.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (96944167..96956424, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (83439922..83450449, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (87434929..87445221)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P2X4 and P2X6 proteins were expressed in a different way during rat small intestine development, showing a higher colocalization coefficient at age P30 in both intestine regions. Those results suggest that purinergic receptors may play a role in intestinal maturation, which is associated with age and intestinal region.
Title: Differential gene expression patterns and colocalization of ATP-gated P2X6/P2X4 ion channels during rat small intestine ontogeny.
The study explores the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in neurons innervating tooth-pulp.
Title: Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp.
P2X(4) and P2X(6) purinoreceptors are present in the gut from birth and that they are differentially distributed among regions
Title: Distribution of the purinegic receptors P2X(4) and P2X(6) during rat gut development.
The P2X6 receptor subunit is widely expressed in neuropils in the whole gray matter except for the dorsal superficial layer of the dorsal horn.
Title: Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.
Results suggest a direct relationship between purinergic P2X2/6 receptor expression and induction of neuronal differentiation in mitogen-free cultured rat neurospheres.
Title: Directed differentiation of neural progenitors into neurons is accompanied by altered expression of P2X purinergic receptors.
The P2X(6) receptors are mainly expressed on intrinsic sensory neurons and that ATP, via P2X(6) receptors probably in heteromeric combination with P2X(2) receptors, may be involved in regulating the physiological functions of these neurons.
Title: Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.
P2X(2) receptors are trimers, whereas the P2X(6) receptor subunits do not form stable oligomers
Title: Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize.

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General gene information

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Markers

AI059538 (e-PCR)
- UniSTS:244545

AI059538 (e-PCR)
- UniSTS:261745

D11Wox5 (e-PCR)
- UniSTS:517791

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in response to ATP	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: P2X purinoceptor 6

Names: ATP receptor; P2X6 receptor; P2XM; purinergic receptor P2X, ligand-gated ion channel, 6; purinergic receptor P2X-like 1 orphan receptor; purinergic receptor P2X6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012721.2 → NP_036853.2 P2X purinoceptor 6

See identical proteins and their annotated locations for NP_036853.2

Status: VALIDATED

Source sequence(s)

CO554543, X92070, X97376

UniProtKB/Swiss-Prot

P51579, R9PXR5

UniProtKB/TrEMBL

A0A8I6ADW0

Related

ENSRNOP00000002558.5, ENSRNOT00000002558.7

Conserved Domains (1) summary

TIGR00863
Location:22 → 376

P2X; cation transporter protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

96944167..96956424 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270294.1 → XP_063126364.1 P2X purinoceptor 6 isoform X7
XM_063270292.1 → XP_063126362.1 P2X purinoceptor 6 isoform X5

UniProtKB/TrEMBL

A0A8I6ATC1
XM_039087989.2 → XP_038943917.1 P2X purinoceptor 6 isoform X2

Related

ENSRNOP00000096439.1

Conserved Domains (1) summary

TIGR00863
Location:46 → 404

P2X; cation transporter protein
XM_039087988.2 → XP_038943916.1 P2X purinoceptor 6 isoform X1

UniProtKB/TrEMBL

A0A8I6ADW0

Conserved Domains (1) summary

TIGR00863
Location:22 → 415

P2X; cation transporter protein
XM_039087991.2 → XP_038943919.1 P2X purinoceptor 6 isoform X8

Conserved Domains (1) summary

cl02993
Location:1 → 226

P2X_receptor; ATP P2X receptor
XM_063270291.1 → XP_063126361.1 P2X purinoceptor 6 isoform X4
XM_039087990.2 → XP_038943918.1 P2X purinoceptor 6 isoform X3

Conserved Domains (1) summary

cl02993
Location:22 → 339

P2X_receptor; ATP P2X receptor
XM_063270293.1 → XP_063126363.1 P2X purinoceptor 6 isoform X6