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    PLBD2 phospholipase B domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 196463, updated on 24-Nov-2021

    Summary

    Official Symbol
    PLBD2provided by HGNC
    Official Full Name
    phospholipase B domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:27283
    See related
    Ensembl:ENSG00000151176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P76
    Expression
    Ubiquitous expression in adrenal (RPKM 36.9), ovary (RPKM 20.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PLBD2 in Genome Data Viewer
    Location:
    12q24.13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (113358576..113391629)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113796392..113829434)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene two pore segment channel 1 Neighboring gene uncharacterized LOC107984436 Neighboring gene solute carrier family 8 member B1 Neighboring gene uncharacterized LOC105369989 Neighboring gene serine dehydratase Neighboring gene serine dehydratase like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in phospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative phospholipase B-like 2
    Names
    76 kDa protein
    LAMA-like protein 2
    PLB homolog 2
    lamina ancestor homolog 2
    mannose-6-phosphate protein associated protein p76
    phospholipase B domain-containing protein 2
    phospholipase B-like 2 32 kDa form
    phospholipase B-like 2 45 kDa form
    NP_001153199.1
    NP_775813.2
    XP_011536325.1
    XP_016874466.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159727.2NP_001153199.1  putative phospholipase B-like 2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC010178
      Consensus CDS
      CCDS53834.1
      UniProtKB/Swiss-Prot
      Q8NHP8
      Related
      ENSP00000443463.2, ENST00000545182.6
      Conserved Domains (1) summary
      pfam04916
      Location:81552
      Phospholip_B; Phospholipase B
    2. NM_173542.4NP_775813.2  putative phospholipase B-like 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_775813.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC010178, BC030618, CN412955
      Consensus CDS
      CCDS9168.1
      UniProtKB/Swiss-Prot
      Q8NHP8
      Related
      ENSP00000280800.3, ENST00000280800.5
      Conserved Domains (1) summary
      pfam04916
      Location:81584
      Phospholip_B; Phospholipase B

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      113358576..113391629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018977.1XP_016874466.1  putative phospholipase B-like 2 isoform X2

    2. XM_011538023.2XP_011536325.1  putative phospholipase B-like 2 isoform X1

      Conserved Domains (1) summary
      pfam04916
      Location:2459
      Phospholip_B; Phospholipase B
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