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    Spn75F Serpin 75F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317912, updated on 29-Dec-2023

    Summary

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    Official Symbol
    Spn75Fprovided by FlyBase
    Official Full Name
    Serpin 75Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052203
    Locus tag
    Dmel_CG32203
    See related
    AllianceGenome:FB:FBgn0052203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6h1; BG642378; BG642378(6h1); CG32203; Dmel\CG32203; FBgn0052203
    Summary
    Involved in multicellular organism reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in COVID-19; alpha-2-plasmin inhibitor deficiency; and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINF2 (serpin family F member 2) and SERPINI1 (serpin family I member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    75F9-75F9; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19128450..19129665, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19121550..19122765, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gemin 2 Neighboring gene uncharacterized protein Neighboring gene frizzled 2 Neighboring gene long non-coding RNA:CR45941 Neighboring gene long non-coding RNA:CR43893

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serpins in arthropod biology. Meekins DA, et al. Semin Cell Dev Biol, 2017 Feb. PMID 27603121, Free PMC Article
    2. Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster. Ravi Ram K, et al. Proc Natl Acad Sci U S A, 2006 Dec 5. PMID 17116868, Free PMC Article
    3. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    4. Sustained post-mating response in Drosophila melanogaster requires multiple seminal fluid proteins. Ram KR, et al. PLoS Genet, 2007 Dec. PMID 18085830, Free PMC Article
    5. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 75F
    Names
    BG642378
    CG32203-PB
    Spn75F-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19128450..19129665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043149.2 → NP_001036614.1  serpin 75F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DMT4, Q3HKQ3
      Conserved Domains (1) summary
      cl00137
      Location:21 → 353
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3HKQ3 Q3HKQ3

    Gene LinkOut

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