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    ZNF205 zinc finger protein 205 [ Homo sapiens (human) ]

    Gene ID: 7755, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF205provided by HGNC
    Official Full Name
    zinc finger protein 205provided by HGNC
    Primary source
    HGNC:HGNC:12996
    See related
    Ensembl:ENSG00000122386 MIM:603436; AllianceGenome:HGNC:12996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RhitH; Zfp13; ZNF210
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of hydrogen peroxide biosynthetic process; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 3.3), ovary (RPKM 2.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    16p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3112586..3120517)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3138563..3147008)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3162587..3170518)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3139191-3139721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3140253-3140782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3142715-3143302 Neighboring gene zinc finger and SCAN domain containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7114 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3151352-3152052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3154929-3155612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3155613-3156296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7118 Neighboring gene uncharacterized LOC124903629 Neighboring gene ZNF205 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3163522-3164110 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3174278-3174547 Neighboring gene ZNF213 antisense RNA 1 (head to head) Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:3177693-3178243 Neighboring gene Sharpr-MPRA regulatory region 2057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10304 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3188465-3188965 Neighboring gene zinc finger protein 213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of two Krüppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. Deng Z, et al. Genomics, 1998 Oct 1. PMID 9787081
    2. A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism. Iida R, et al. Mol Cell Biol, 2010 May. PMID 20231359, Free PMC Article
    3. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. Iida R, et al. Free Radic Biol Med, 2012 Apr 15. PMID 22306510
    4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. Yeung ML, et al. J Biol Chem, 2009 Jul 17. PMID 19460752, Free PMC Article
    5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF205 positively regulates RLR antiviral signaling by targeting RIG-I.
      Title: ZNF205 positively regulates RLR antiviral signaling by targeting RIG-I.
    2. that knockdown of RhitH or overexpression of M-LPH reduces the generation of intracellular H(2)O(2) and loss of mitochondrial membrane potential caused by an inhibitor of the respiratory chain, antimycin A
      Title: Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 205 (ZNF205) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hydrogen peroxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional repressor RHIT
    Names
    repressor of heat-inducible transcription
    transcriptional repressor RhitH
    zinc finger protein 210

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042428.2 → NP_001035893.1  transcriptional repressor RHIT

      See identical proteins and their annotated locations for NP_001035893.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' non-coding region and has a shorter 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC108134, BM924902, CB152017
      Consensus CDS
      CCDS10494.2
      UniProtKB/Swiss-Prot
      A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
      Related
      ENSP00000219091.4, ENST00000219091.9
      Conserved Domains (6) summary
      smart00349
      Location:124 → 168
      KRAB; krueppel associated box
      COG5048
      Location:306 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:422 → 442
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:476 → 498
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:124 → 161
      KRAB; KRAB box
      pfam13465
      Location:434 → 459
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001278158.2 → NP_001265087.1  transcriptional repressor RHIT

      See identical proteins and their annotated locations for NP_001265087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate donor splice site in the 5' non-coding region and has a longer 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AB672633, AF060865, BC002810
      Consensus CDS
      CCDS10494.2
      UniProtKB/Swiss-Prot
      A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
      Related
      ENSP00000480401.1, ENST00000620094.4
      Conserved Domains (6) summary
      smart00349
      Location:124 → 168
      KRAB; krueppel associated box
      COG5048
      Location:306 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:422 → 442
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:476 → 498
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:124 → 161
      KRAB; KRAB box
      pfam13465
      Location:434 → 459
      zf-H2C2_2; Zinc-finger double domain

    3. NM_003456.3 → NP_003447.2  transcriptional repressor RHIT

      See identical proteins and their annotated locations for NP_003447.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AF060865, BI826058, CB152017
      Consensus CDS
      CCDS10494.2
      UniProtKB/Swiss-Prot
      A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
      Related
      ENSP00000371627.3, ENST00000382192.7
      Conserved Domains (6) summary
      smart00349
      Location:124 → 168
      KRAB; krueppel associated box
      COG5048
      Location:306 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:422 → 442
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:476 → 498
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:124 → 161
      KRAB; KRAB box
      pfam13465
      Location:434 → 459
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3112586..3120517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255558.3 → XP_005255615.1  transcriptional repressor RHIT isoform X1

      See identical proteins and their annotated locations for XP_005255615.1

      UniProtKB/Swiss-Prot
      A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
      Conserved Domains (6) summary
      smart00349
      Location:124 → 168
      KRAB; krueppel associated box
      COG5048
      Location:306 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:422 → 442
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:476 → 498
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:124 → 161
      KRAB; KRAB box
      pfam13465
      Location:434 → 459
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047434601.1 → XP_047290557.1  transcriptional repressor RHIT isoform X1

      UniProtKB/Swiss-Prot
      A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3138563..3147008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313870.1 → XP_054169845.1  transcriptional repressor RHIT isoform X1

    2. XM_054313869.1 → XP_054169844.1  transcriptional repressor RHIT isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95201.2 GenPept UniProtKB/Swiss-Prot:O95201

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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