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    SEPTIN4 septin 4 [ Homo sapiens (human) ]

    Gene ID: 5414, updated on 11-Apr-2024

    Summary

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    Official Symbol
    SEPTIN4provided by HGNC
    Official Full Name
    septin 4provided by HGNC
    Primary source
    HGNC:HGNC:9165
    See related
    Ensembl:ENSG00000108387 MIM:603696; AllianceGenome:HGNC:9165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H5; ARTS; MART; SEP4; CE5B3; SEPT4; PNUTL2; hucep-7; BRADEION; C17orf47; Septin-4; hCDCREL-2
    Summary
    This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]
    Expression
    Biased expression in brain (RPKM 37.9), adrenal (RPKM 26.6) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SEPTIN4 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (58520256..58544328, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (59388127..59412197, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56597617..56621689, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8770 Neighboring gene SET pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8771 Neighboring gene myotubularin related protein 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:56595757-56596502 Neighboring gene SEPTIN4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56606301-56606801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56608575-56609075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12485 Neighboring gene MPRA-validated peak2918 silencer Neighboring gene uncharacterized LOC107985048 Neighboring gene testis expressed 14, intercellular bridge forming factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12487 Neighboring gene uncharacterized LOC124904154

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Biallelic loss-of-function mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humans. Wang G, et al. Hum Mutat, 2022 Dec. PMID 36135717
    2. Septin4 regulates endoplasmic reticulum stress and apoptosis in melatonin‑induced osteoblasts. Tao L, et al. Mol Med Rep, 2020 Aug. PMID 32626973, Free PMC Article
    3. Untangling the Tauopathy for Alzheimer's disease and parkinsonism. Chang HY, et al. J Biomed Sci, 2018 Jul 10. PMID 29991349, Free PMC Article
    4. Septin4_i1 regulates apoptosis in hepatic stellate cells through peroxisome proliferator-activated receptor-γ/Akt/B-cell lymphoma 2 pathway. Zhu D, et al. J Histochem Cytochem, 2015 Mar. PMID 25527525, Free PMC Article
    5. Expression of Septin4 in human hepatic stellate cells LX-2 stimulated by LPS. Sun X, et al. Inflammation, 2013 Jun. PMID 23180367

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ARTS of p53-dependent mitochondrial apoptosis.
      Title: The ARTS of p53-dependent mitochondrial apoptosis.
    2. Biallelic loss-of-function mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humans.
      Title: Biallelic loss-of-function mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humans.
    3. p53 induces ARTS to promote mitochondrial apoptosis.
      Title: p53 induces ARTS to promote mitochondrial apoptosis.
    4. Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.
      Title: Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.
    5. Septin4 regulates endoplasmic reticulum stress and apoptosis in melatonininduced osteoblasts.
      Title: Septin4 regulates endoplasmic reticulum stress and apoptosis in melatonin‑induced osteoblasts.
    6. carnosic acid induces parkin by enhancing the ubiquitination of ARTS, leading to induction of XIAP.
      Title: Modulation of ARTS and XIAP by Parkin Is Associated with Carnosic Acid Protects SH-SY5Y Cells against 6-Hydroxydopamine-Induced Apoptosis.
    7. In this review, we will discuss the recent advances of the tauopathy research, primarily focusing on its association with the early axonal manifestation of axonal transport defect, axonal mitochondrial stress, autophagic vesicle accumulation and the proceeding of axon destruction, and the pathogenic Tau spreading across the synapse.
      Title: Untangling the Tauopathy for Alzheimer's disease and parkinsonism.
    8. Septin4 is a novel essential factor involved in oxidative stress induced vascular endothelial cell injury by interacting with apoptosis-related protein PARP1.
      Title: Septin4 as a novel binding partner of PARP1 contributes to oxidative stress induced human umbilical vein endothelial cells injure.
    9. The data suggest that Sept4_i1 induces hepatic stellate cell apoptosis by inhibiting Akt and Bcl-2 expression and up-regulating PPAR-gamma expression.
      Title: Septin4_i1 regulates apoptosis in hepatic stellate cells through peroxisome proliferator-activated receptor-γ/Akt/B-cell lymphoma 2 pathway.
    10. results suggest that Septin4 may be involved in the process of activation of hepatic stellate cells by lipopolysaccharide stimulation.
      Title: Expression of Septin4 in human hepatic stellate cells LX-2 stimulated by LPS.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis identifies four new loci associated with testicular germ cell tumor.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40121, MGC33599

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hematopoietic stem cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm annulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm annulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin-4
    Names
    CE5B3 beta
    apoptosis-related protein in the TGF-beta signaling pathway
    bradeion beta
    brain protein H5
    cell division control-related protein 2
    cerebral protein 7
    peanut-like protein 2
    septin-M
    uncharacterized protein C17orf47

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029570.1 RefSeqGene

      Range
      1491..25563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038704.4 → NP_001033793.3  septin-4 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC005666, AK097440, BC022189
      Consensus CDS
      CCDS32691.1
      Related
      ENSP00000354874.2, ENST00000321691.3
      Conserved Domains (1) summary
      pfam15548
      Location:2 → 534
      DUF4655; Domain of unknown function (DUF4655)

    2. NM_001198713.2 → NP_001185642.1  septin-4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate 5' exon compared to variant 7, resulting in translation initiation from an alternate start codon and a shorter isoform (4) with a distinct N-terminus compared to isoform 5. This variant appears to be testis-specific.
      Source sequence(s)
      AF073312, AK301914
      Consensus CDS
      CCDS56041.1
      UniProtKB/Swiss-Prot
      O43236
      Related
      ENSP00000414779.3, ENST00000412945.7
      Conserved Domains (2) summary
      COG5019
      Location:116 → 468
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:133 → 406
      Septin; Septin

    3. NM_001256782.2 → NP_001243711.1  septin-4 isoform 5

      See identical proteins and their annotated locations for NP_001243711.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes the longest isoform (5).
      Source sequence(s)
      AK294094, AK301914, BC142968
      Consensus CDS
      CCDS58582.1
      UniProtKB/Swiss-Prot
      O43236
      Related
      ENSP00000402000.2, ENST00000457347.6
      Conserved Domains (2) summary
      COG5019
      Location:139 → 491
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:156 → 429
      Septin; Septin

    4. NM_001256822.2 → NP_001243751.1  septin-4 isoform 6

      See identical proteins and their annotated locations for NP_001243751.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 7. The encoded isoform (6) is shorter than isoform 5.
      Source sequence(s)
      AC005666, AK294094, DA343015
      Consensus CDS
      CCDS58581.1
      UniProtKB/TrEMBL
      J3QRT6
      Related
      ENSP00000463768.1, ENST00000583114.5
      Conserved Domains (1) summary
      pfam00735
      Location:1 → 267
      Septin; Septin

    5. NM_001363803.2 → NP_001350732.1  septin-4 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC005666
      Consensus CDS
      CCDS86620.1
      UniProtKB/TrEMBL
      J3KSZ7, J3QRT6
      Related
      ENSP00000462727.1, ENST00000580844.5
      Conserved Domains (1) summary
      pfam00735
      Location:43 → 315
      Septin; Septin

    6. NM_001368771.2 → NP_001355700.1  septin-4 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC005666
      Consensus CDS
      CCDS92368.1
      Related
      ENSP00000500383.1, ENST00000672673.2
      Conserved Domains (2) summary
      pfam00735
      Location:660 → 932
      Septin
      pfam15548
      Location:2 → 534
      DUF4655; Domain of unknown function (DUF4655)

    7. NM_001368772.2 → NP_001355701.1  septin-4 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC005666
      Conserved Domains (1) summary
      pfam00735
      Location:135 → 407
      Septin

    8. NM_004574.5 → NP_004565.1  septin-4 isoform 1

      See identical proteins and their annotated locations for NP_004565.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 7. It encodes isoform 1 (also known as PNUTL2a, H5, SEPT4_i1, bradeion beta, hcdcrel2a) which contains a distinct N-terminus and is shorter, compared to isoform 5.
      Source sequence(s)
      AF073312, DA076433
      Consensus CDS
      CCDS11610.1
      UniProtKB/Swiss-Prot
      A0A5F9ZHH3, B2RD42, B3KSX9, B4DXC6, B4DXV5, O43236, Q6IAP3, Q8N821, Q8NEP4, Q9H315, Q9UM58
      Related
      ENSP00000321674.3, ENST00000317268.7
      Conserved Domains (1) summary
      pfam00735
      Location:142 → 414
      Septin; Septin

    9. NM_080415.4 → NP_536340.1  septin-4 isoform 2

      See identical proteins and their annotated locations for NP_536340.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 7. This transcript contains an early translation termination site, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, the encoded protein (isoform 2, also known as ARTS, SEPT4_i2), with distinct N- and C-termini compared to isoform 5, has been shown to be expressed in vivo, and characterized as a mitochondrial pro-apoptotic, tumor suppressor protein having a role in cancer (PMIDs: 11146656, 15254396).
      Source sequence(s)
      AF176379, DC361494
      Consensus CDS
      CCDS45743.1
      UniProtKB/Swiss-Prot
      O43236
      Related
      ENSP00000402348.1, ENST00000426861.5
      Conserved Domains (1) summary
      cl21455
      Location:122 → 250
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    10. NM_080416.4 → NP_536341.1  septin-4 isoform 3

      See identical proteins and their annotated locations for NP_536341.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 7. It encodes isoform 3 (also known as PNUTL2b, hcdcrel2b) with a distinct N-terminus compared to isoform 5.
      Source sequence(s)
      AF073312, DC361494
      Consensus CDS
      CCDS11609.1
      UniProtKB/Swiss-Prot
      O43236
      Related
      ENSP00000321071.6, ENST00000317256.10
      Conserved Domains (2) summary
      COG5019
      Location:105 → 457
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:122 → 395
      Septin; Septin

    RNA

    1. NR_037155.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' and 3' exon structure, compared to variant 7. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB002110, AK294094, DA076433
      Related
      ENST00000583273.5

    2. NR_104196.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate 5' and 3' exon structure, compared to variant 7. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005666, AK294094, AK315045, DA180095
      Related
      ENST00000584488.5

    3. NR_104197.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate 5' exon structure and includes an alternate internal segment, compared to variant 7. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005666, AK294094, BC018055, DC361494

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      58520256..58544328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436309.1 → XP_047292265.1  septin-4 isoform X4

    2. XM_024450808.2 → XP_024306576.1  septin-4 isoform X8

      UniProtKB/TrEMBL
      J3QRT6
      Conserved Domains (1) summary
      pfam00735
      Location:1 → 267
      Septin; Septin

    3. XM_006721952.4 → XP_006722015.1  septin-4 isoform X7

      UniProtKB/TrEMBL
      J3QRT6
      Conserved Domains (2) summary
      COG5019
      Location:6 → 358
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:23 → 296
      Septin; Septin

    4. XM_006721950.5 → XP_006722013.1  septin-4 isoform X6

      UniProtKB/TrEMBL
      J3QRT6
      Conserved Domains (2) summary
      COG5019
      Location:30 → 382
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:47 → 320
      Septin; Septin

    5. XM_006721949.4 → XP_006722012.1  septin-4 isoform X5

      See identical proteins and their annotated locations for XP_006722012.1

      Conserved Domains (2) summary
      COG5019
      Location:129 → 481
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:146 → 419
      Septin; Septin

    6. XM_006721955.4 → XP_006722018.1  septin-4 isoform X8

      See identical proteins and their annotated locations for XP_006722018.1

      UniProtKB/TrEMBL
      J3QRT6
      Conserved Domains (1) summary
      pfam00735
      Location:1 → 267
      Septin; Septin

    7. XM_011524912.3 → XP_011523214.1  septin-4 isoform X8

      See identical proteins and their annotated locations for XP_011523214.1

      UniProtKB/TrEMBL
      J3QRT6
      Conserved Domains (1) summary
      pfam00735
      Location:1 → 267
      Septin; Septin

    8. XM_047436307.1 → XP_047292263.1  septin-4 isoform X1

    9. XM_047436308.1 → XP_047292264.1  septin-4 isoform X2

    10. XM_011524637.3 → XP_011522939.1  septin-4 isoform X3

      Conserved Domains (1) summary
      pfam15548
      Location:2 → 534
      DUF4655; Domain of unknown function (DUF4655)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      59388127..59412197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316522.1 → XP_054172497.1  septin-4 isoform X4

    2. XM_054316528.1 → XP_054172503.1  septin-4 isoform X8

    3. XM_054316525.1 → XP_054172500.1  septin-4 isoform X7

    4. XM_054316524.1 → XP_054172499.1  septin-4 isoform X6

    5. XM_054316523.1 → XP_054172498.1  septin-4 isoform X5

    6. XM_054316526.1 → XP_054172501.1  septin-4 isoform X8

    7. XM_054316527.1 → XP_054172502.1  septin-4 isoform X8

    8. XM_054316519.1 → XP_054172494.1  septin-4 isoform X1

    9. XM_054316520.1 → XP_054172495.1  septin-4 isoform X2

    10. XM_054316521.1 → XP_054172496.1  septin-4 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_080417.1: Suppressed sequence

      Description
      NM_080417.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43236.1 GenPept UniProtKB/Swiss-Prot:O43236

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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