Rbsn rabenosyn, RAB effector [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rbsnprovided by RGD
Full Name: rabenosyn, RAB effectorprovided by RGD
Primary source: RGD:1305397
See related: Ensembl:ENSRNOG00000011391 AllianceGenome:RGD:1305397
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zfyve20
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to lysosome transport; early endosome to Golgi transport; and regulation of Golgi organization. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 83.0), Brain (RPKM 82.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (126239354..126269702, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (124682228..124712578, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (124050559..124080919, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128573 (e-PCR)
- UniSTS:211881

RH140623 (e-PCR)
- UniSTS:222692

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in early endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rabenosyn-5

Names: zinc finger, FYVE domain containing 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107875.1 → NP_001101345.1 rabenosyn-5

See identical proteins and their annotated locations for NP_001101345.1

Status: PROVISIONAL

Source sequence(s)

CH473957

UniProtKB/TrEMBL

A6IBC3, D3ZL11

Related

ENSRNOP00000015602.3, ENSRNOT00000015602.5

Conserved Domains (3) summary

cd15716
Location:150 → 261

FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins

pfam11464
Location:460 → 498

Rbsn; Rabenosyn Rab binding domain

pfam16601
Location:548 → 726

NPF; Rabosyn-5 repeating NPF sequence-motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

126239354..126269702 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107619.2 → XP_038963547.1 rabenosyn-5 isoform X4

Conserved Domains (3) summary

cd15716
Location:62 → 173

FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins

pfam11464
Location:372 → 410

Rbsn; Rabenosyn Rab binding domain

pfam16601
Location:460 → 638

NPF; Rabosyn-5 repeating NPF sequence-motif
XM_039107618.2 → XP_038963546.1 rabenosyn-5 isoform X1

Conserved Domains (3) summary

cd15716
Location:148 → 259

FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins

pfam11464
Location:458 → 496

Rbsn; Rabenosyn Rab binding domain

pfam16601
Location:546 → 724

NPF; Rabosyn-5 repeating NPF sequence-motif
XM_063286076.1 → XP_063142146.1 rabenosyn-5 isoform X3
XM_006236908.5 → XP_006236970.1 rabenosyn-5 isoform X2

Conserved Domains (3) summary

cd15716
Location:120 → 231

FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins

pfam11464
Location:427 → 466

Rbsn; Rabenosyn Rab binding domain

pfam16601
Location:518 → 696

NPF; Rabosyn-5 repeating NPF sequence-motif