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    Pacc1 proton activated chloride channel 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305070, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pacc1provided by RGD
    Official Full Name
    proton activated chloride channel 1provided by RGD
    Primary source
    RGD:1359339
    See related
    Ensembl:ENSRNOG00000003915 AllianceGenome:RGD:1359339
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PAC; Tmem206; RGD1359339
    Summary
    Predicted to enable pH-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within anion transmembrane transport and inorganic anion transport. Predicted to be integral component of plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human PACC1 (proton activated chloride channel 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 138.6), Spleen (RPKM 88.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pacc1 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105435772..105460877)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102904668..102929770)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (110006975..110032790)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555043 Neighboring gene uncharacterized LOC102555129 Neighboring gene uncharacterized LOC134481545 Neighboring gene neudesin neurotrophic factor Neighboring gene protein phosphatase 2, regulatory subunit B', alpha Neighboring gene uncharacterized LOC120096352

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. Ullrich F, et al. Elife, 2019 Jul 18. PMID 31318332, Free PMC Article
    2. PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. Yang J, et al. Science, 2019 Apr 26. PMID 31023925, Free PMC Article
    3. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95217

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pH-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pH-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pH-gated chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proton-activated chloride channel
    Names
    transmembrane protein 206

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007679.1 → NP_001007680.1  proton-activated chloride channel

      See identical proteins and their annotated locations for NP_001007680.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082061
      UniProtKB/Swiss-Prot
      Q66H28
      UniProtKB/TrEMBL
      A0A8I5ZNJ7, A6JGZ6
      Related
      ENSRNOP00000005387.4, ENSRNOT00000005387.7
      Conserved Domains (1) summary
      pfam15122
      Location:55 → 349
      TMEM206; TMEM206 protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      105435772..105460877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250481.5 → XP_006250543.1  proton-activated chloride channel isoform X1

      Conserved Domains (1) summary
      pfam15122
      Location:44 → 279
      TMEM206; TMEM206 protein family

    2. XM_063272397.1 → XP_063128467.1  proton-activated chloride channel isoform X2

    RNA

    1. XR_010056921.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H28.1 GenPept UniProtKB/Swiss-Prot:Q66H28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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