Ptgdr2 prostaglandin D2 receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgdr2provided by RGD
Official Full Name: prostaglandin D2 receptor 2provided by RGD
Primary source: RGD:1311986
See related: Ensembl:ENSRNOG00000036631 AllianceGenome:RGD:1311986
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr44
Summary: Predicted to enable neuropeptide binding activity and prostaglandin receptor activity. Predicted to be involved in calcium-mediated signaling; chemotaxis; and neuropeptide signaling pathway. Predicted to act upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of male germ cell proliferation; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 83.4), Lung (RPKM 29.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (217010183..217015044)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207585088..207590275)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226976455..226995641)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRTh2 mediates most prostaglandin D2 pro-inflammatory effects and long receptor residence time of antagonist LAS191859 translates into long-lasting in vivo efficacy.
Title: Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy.
Production of prostaglandin D2 followed by eosinophil recruitment into the airways via a CRTH2 receptor are the major pathogenic factors responsible for the A. fumigatus-induced enhancement of airway inflammation and responsiveness.
Title: Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus.
We believe that PGD2 signaling via DP2 signaling pathway from microglia to neurons is one of the triggering factors for mechanical allodynia in this neuropathic pain model.
Title: COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin D receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin D receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin D receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin F receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin J receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of male germ cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostaglandin D2 receptor 2

Names: G protein-coupled receptor 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012070.1 → NP_001012070.1 prostaglandin D2 receptor 2

See identical proteins and their annotated locations for NP_001012070.1

Status: PROVISIONAL

Source sequence(s)

AY228550

UniProtKB/Swiss-Prot

Q6XKD3

Related

ENSRNOP00000066082.1, ENSRNOT00000054808.5

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 314

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

217010183..217015044

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264453.1 → XP_063120523.1 prostaglandin D2 receptor 2 isoform X1

UniProtKB/Swiss-Prot

Q6XKD3
XM_039079849.2 → XP_038935777.1 prostaglandin D2 receptor 2 isoform X1

UniProtKB/Swiss-Prot

Q6XKD3

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 314

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_063264455.1 → XP_063120525.1 prostaglandin D2 receptor 2 isoform X1

UniProtKB/Swiss-Prot

Q6XKD3
XM_039079846.2 → XP_038935774.1 prostaglandin D2 receptor 2 isoform X1

UniProtKB/Swiss-Prot

Q6XKD3

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 314

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039079847.2 → XP_038935775.1 prostaglandin D2 receptor 2 isoform X1

UniProtKB/Swiss-Prot

Q6XKD3

Conserved Domains (2) summary

cd14964
Location:33 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 314

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily