Sst somatostatin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sstprovided by RGD
Official Full Name: somatostatinprovided by RGD
Primary source: RGD:3761
See related: Ensembl:ENSRNOG00000001837 AllianceGenome:RGD:3761
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SRIF; Smst; SS-14; SS-28
Summary: Predicted to enable identical protein binding activity. Involved in several processes, including hyperosmotic response; response to acidic pH; and response to heat. Located in extracellular space and neuronal cell body. Biomarker of gastric ulcer; hypertension; and vascular dementia. Orthologous to human SST (somatostatin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 490.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (90461546..90462823)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (76956896..76958173)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (80358172..80359449)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study suggested that somatostatin and nNOS are expressed in most interneurons whereas CB1 receptor is present in both interneurons and projection neurons in hippocampal regions
Title: Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hippocampus.
Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-cells.
Title: Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells.
Results suggest that somatostatin suppresses GABA release from the amacrine cells by inhibiting presynaptic Ca2+ channels, in part through activating sst5/sst2 receptors, a process that is mediated by the intracellular cAMP-PKA signaling pathway
Title: Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells.
These results suggest that a local release of somatostatin facilitates the excitability of trigeminal nocicepitve C1 neuronal activity via inhibition of GABAergic neurons
Title: Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons.
when activated by SST-14, SSTR2A internalizes and recycles via the Golgi, which requires ECE-1 degradation of SST-14 and receptor dissociation from beta-arrestins
Title: Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons.
The aim of this study was to define all the areas of changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic somatostatin (SS) and neuropeptide Y (NPY) in rat brain during experimental ischemia.
Title: The role of C-Fos protein, somatostatin and neuropeptide Y in the pathogenesis of ischemic brain injuries based on animal model of cerebral ischemia.
Helicobacter pylori is capable of inhibiting acid secretion directly as well as indirectly by activating intramural CGRP sensory neurons coupled to stimulation of SST and inhibition of histamine secretion.
Title: H. pylori acutely inhibits gastric secretion by activating CGRP sensory neurons coupled to stimulation of somatostatin and inhibition of histamine secretion.
Data suggest that neuronostatin action to reduce food intake and water intake is mediated through melanocortin 3/4 receptors, not through oxytocin receptors.
Title: The melanocortins, not oxytocin, mediate the anorexigenic and antidipsogenic effects of neuronostatin.
both ferret odor exposure and elevated plus maze exposure resulted in increased somatostatin
Title: Comparison of the activation of somatostatin- and neuropeptide Y-containing neuronal populations of the rat amygdala following two different anxiogenic stressors.
This study provides structural evidence that SST immunoreactivity in the pre-BotC is highly expressed in somas, terminals, and primary dendrites, and overlapped with small fusiform NK1R-ir neurons.
Title: Synaptic relationship between somatostatin- and neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats.

Submit: New GeneRIF Correction See all GeneRIFs (53)

General gene information

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Markers

SST-112F (e-PCR)
- UniSTS:25600

RH94876 (e-PCR)
- UniSTS:120122

D11Wox2 (e-PCR)
- UniSTS:118094

RH127971 (e-PCR)
- UniSTS:211281

D11Arb1 (e-PCR)
- UniSTS:239700

PMC123023P2 (e-PCR)
- UniSTS:270423

PMC24644P1 (e-PCR)
- UniSTS:272267

X51468 (e-PCR)
- UniSTS:180877

d11mit7 (e-PCR)
- UniSTS:120750

UniSTS:256695 (e-PCR)
- UniSTS:256695

Sst (e-PCR), detects polymorphism
- UniSTS:256695

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in hyperosmotic response	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info
involved_in response to acidic pH	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organonitrogen compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in somatostatin signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: somatostatin

Names: somatotropin release-inhibiting factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.