Cep170 centrosomal protein 170 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cep170provided by RGD
Full Name: centrosomal protein 170provided by RGD
Primary source: RGD:621868
See related: Ensembl:ENSRNOG00000004127 AllianceGenome:RGD:621868
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kab; KAB1; Rhk1
Summary: Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to be part of centriolar subdistal appendage. Orthologous to human CEP170 (centrosomal protein 170). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 252.9), Thymus (RPKM 183.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (91201808..91285990, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (88669672..88754011, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (94807090..94887448, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

molecular cloning; localized in cell nucleus and in the condensed chromosome during the mitotic cell division; works as a protective protein against cell damage by oxidative stress
Title: Molecular cloning and characterization of rKAB1, which interacts with KARP-1, localizes in the nucleus and protects cells against oxidative death.

Submit: New GeneRIF Correction

General gene information

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Markers

BF396392 (e-PCR)
- UniSTS:245764

RH132374 (e-PCR)
- UniSTS:215657

BE115808 (e-PCR)
- UniSTS:248220

BQ205581 (e-PCR)
- UniSTS:261289

BE108380 (e-PCR)
- UniSTS:247740

Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
part_of centriolar subdistal appendage	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosomal protein of 170 kDa

Names: KARP-1 binding protein 1; centrosomal protein 170kDa; centrosomal protein of 170 kDa-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427216.1 → NP_001414145.1 centrosomal protein of 170 kDa

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

91201808..91285990 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272008.1 → XP_063128078.1 centrosomal protein of 170 kDa isoform X16
XM_063272007.1 → XP_063128077.1 centrosomal protein of 170 kDa isoform X15
XM_063272006.1 → XP_063128076.1 centrosomal protein of 170 kDa isoform X14
XM_063272005.1 → XP_063128075.1 centrosomal protein of 170 kDa isoform X13
XM_063272004.1 → XP_063128074.1 centrosomal protein of 170 kDa isoform X12
XM_063272003.1 → XP_063128073.1 centrosomal protein of 170 kDa isoform X11
XM_063272002.1 → XP_063128072.1 centrosomal protein of 170 kDa isoform X10
XM_063272000.1 → XP_063128070.1 centrosomal protein of 170 kDa isoform X8
XM_063271999.1 → XP_063128069.1 centrosomal protein of 170 kDa isoform X7

UniProtKB/TrEMBL

D3ZET9, F1LNI7
XM_063272001.1 → XP_063128071.1 centrosomal protein of 170 kDa isoform X9
XM_063271998.1 → XP_063128068.1 centrosomal protein of 170 kDa isoform X6
XM_063271997.1 → XP_063128067.1 centrosomal protein of 170 kDa isoform X5
XM_063271996.1 → XP_063128066.1 centrosomal protein of 170 kDa isoform X4
XM_063271995.1 → XP_063128065.1 centrosomal protein of 170 kDa isoform X3
XM_063271994.1 → XP_063128064.1 centrosomal protein of 170 kDa isoform X2
XM_063271993.1 → XP_063128063.1 centrosomal protein of 170 kDa isoform X1
XM_063272009.1 → XP_063128079.1 centrosomal protein of 170 kDa isoform X17

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_134416.1: Suppressed sequence

Description

NM_134416.1: This RefSeq was temporarily suppressed because there were several mismatches, insertions, and deletions compared to available sequence data. These differences resulted in a protein that was truncated at both ends and