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    Uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361805, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Uqcc2provided by RGD
    Official Full Name
    ubiquinol-cytochrome c reductase complex assembly factor 2provided by RGD
    Primary source
    RGD:1306917
    See related
    Ensembl:ENSRNOG00000025909 AllianceGenome:RGD:1306917
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    M19; Mnf1; RGD1306917
    Summary
    Predicted to be involved in several processes, including mitochondrial respiratory chain complex III assembly; positive regulation of mitochondrial translation; and regulation of insulin secretion. Predicted to be located in mitochondrion and nuclear body. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 7. Orthologous to human UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 325.3), Heart (RPKM 258.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5204682..5217080, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5202837..5214541, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5712200..5723902, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-trisphosphate receptor, type 3 Neighboring gene uncharacterized LOC134483859 Neighboring gene uncharacterized LOC120098963 Neighboring gene inositol hexakisphosphate kinase 3 Neighboring gene uncharacterized LOC108353257

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. M19 modulates skeletal muscle differentiation and insulin secretion in pancreatic β-cells through modulation of respiratory chain activity. Cambier L, et al. PLoS One, 2012. PMID 22363741, Free PMC Article
    2. Association of a novel mitochondrial protein M19 with mitochondrial nucleoids. Sumitani M, et al. J Biochem, 2009 Nov. PMID 19643811
    3. Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression. Tucker EJ, et al. PLoS Genet, 2013. PMID 24385928, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of oxidative phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of skeletal muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinol-cytochrome-c reductase complex assembly factor 2
    Names
    mitochondrial nucleoid factor 1
    mitochondrial protein M19
    NP_001101998.1
    XP_038954739.1
    XP_038954740.1
    XP_038954741.1
    XP_063135283.1
    XP_063135284.1
    XP_063135285.1
    XP_063135286.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108528.1 → NP_001101998.1  ubiquinol-cytochrome-c reductase complex assembly factor 2

      See identical proteins and their annotated locations for NP_001101998.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473988
      UniProtKB/Swiss-Prot
      B5DFN3
      UniProtKB/TrEMBL
      D3Z949

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5204682..5217080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279213.1 → XP_063135283.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X1

    2. XM_039098811.2 → XP_038954739.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QIN0

    3. XM_063279214.1 → XP_063135284.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X2

    4. XM_063279216.1 → XP_063135286.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X3

    5. XM_063279215.1 → XP_063135285.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X3

    6. XM_039098812.2 → XP_038954740.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QIN0
      Related
      ENSRNOP00000036200.5

    7. XM_039098813.2 → XP_038954741.1  ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QIN0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5DFN3.1 GenPept UniProtKB/Swiss-Prot:B5DFN3

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