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    Nudt9 nudix hydrolase 9 [ Mus musculus (house mouse) ]

    Gene ID: 74167, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nudt9provided by MGI
    Official Full Name
    nudix hydrolase 9provided by MGI
    Primary source
    MGI:MGI:1921417
    See related
    Ensembl:ENSMUSG00000029310 AllianceGenome:MGI:1921417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADPR-PPase; 1190002C07Rik
    Summary
    Enables ADP-ribose diphosphatase activity. Acts upstream of or within ADP catabolic process and IDP catabolic process. Located in mitochondrion. Is expressed in alimentary system; cranium; liver; nervous system; and retina. Orthologous to human NUDT9 (nudix hydrolase 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 57.6), adrenal adult (RPKM 40.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nudt9 in Genome Data Viewer
    Location:
    5 E5; 5 50.54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104193407..104213244)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104045538..104065378)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:104436899-104437123 Neighboring gene STARR-seq mESC enhancer starr_13817 Neighboring gene STARR-seq mESC enhancer starr_13818 Neighboring gene STARR-positive B cell enhancer ABC_E2165 Neighboring gene microRNA 5619 Neighboring gene predicted gene, 52783 Neighboring gene secretory calcium-binding phosphoprotein proline-glutamine rich 1 Neighboring gene SPARC-like 1 Neighboring gene STARR-seq mESC enhancer starr_13821 Neighboring gene predicted gene, 26703

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. Carloto A, et al. Biochim Biophys Acta, 2006 Oct. PMID 16860484
    2. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. Perraud AL, et al. J Biol Chem, 2003 Jan 17. PMID 12427752
    3. Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose). Lin S, et al. Biochim Biophys Acta, 2002 Jan 31. PMID 11825615
    4. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Perraud AL, et al. Nature, 2001 May 31. PMID 11385575
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADP-ribose hydrolysis is catalysed by NDP-sugar/alcohol pyrophosphatases of differing specificity, including a highly specific, low-K(m) ADP-ribose pyrophosphatase.
      Title: The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP-ribose diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ADP-ribose diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ADP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribose pyrophosphatase, mitochondrial
    Names
    ADP-ribose diphosphatase
    ADP-ribose phosphohydrolase
    adenosine diphosphoribose pyrophosphatase
    nucleoside diphosphate-linked moiety X motif 9
    nudix (nucleoside diphosphate linked moiety X)-type motif 9
    nudix motif 9
    NP_083070.2
    XP_006535319.1
    XP_006535320.1
    XP_030110706.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028794.4 → NP_083070.2  ADP-ribose pyrophosphatase, mitochondrial

      See identical proteins and their annotated locations for NP_083070.2

      Status: VALIDATED

      Source sequence(s)
      AK158058, AL714024, BY237462
      Consensus CDS
      CCDS19482.1
      UniProtKB/Swiss-Prot
      A2AH31, Q3TZ68, Q8BVU5, Q8K1J4
      Related
      ENSMUSP00000031250.8, ENSMUST00000031250.14
      Conserved Domains (1) summary
      cd03670
      Location:149 → 335
      ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      104193407..104213244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535257.5 → XP_006535320.1  ADP-ribose pyrophosphatase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd03670
      Location:111 → 274
      ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

    2. XM_006535256.5 → XP_006535319.1  ADP-ribose pyrophosphatase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006535319.1

      Conserved Domains (1) summary
      cd03670
      Location:99 → 285
      ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

    3. XM_030254846.2 → XP_030110706.1  ADP-ribose pyrophosphatase, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd03670
      Location:61 → 224
      ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVU5.1 GenPept UniProtKB/Swiss-Prot:Q8BVU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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