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    Cpeb4 cytoplasmic polyadenylation element binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 67579, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cpeb4provided by MGI
    Official Full Name
    cytoplasmic polyadenylation element binding protein 4provided by MGI
    Primary source
    MGI:MGI:1914829
    See related
    Ensembl:ENSMUSG00000020300 AllianceGenome:MGI:1914829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cpeb-4; Cpe-bp4; mCPEB-4
    Summary
    Enables RNA binding activity. Involved in cellular response to amino acid stimulus and response to ischemia. Located in several cellular components, including dendrite; endoplasmic reticulum; and postsynaptic density. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and sensory organ. Orthologous to human CPEB4 (cytoplasmic polyadenylation element binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 15.0), liver E14.5 (RPKM 14.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A4; 11 18.66 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (31820911..31885635)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (31870104..31935635)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630024D03 gene Neighboring gene STARR-seq mESC enhancer starr_29094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31732062-31732171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31732356-31732509 Neighboring gene predicted gene, 39675 Neighboring gene predicted gene 12107 Neighboring gene STARR-positive B cell enhancer ABC_E2352 Neighboring gene STARR-positive B cell enhancer mm9_chr11:31822573-31822874 Neighboring gene von Hippel-Lindau binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2982 Neighboring gene RIKEN cDNA 4930524B15 gene Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene predicted gene, 35267

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway. Shi M, et al. Funct Integr Genomics, 2022 Dec. PMID 35909199
    2. Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development. Sibilio A, et al. iScience, 2022 Feb 18. PMID 35243213, Free PMC Article
    3. The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation. Arasaki Y, et al. Biochem Biophys Res Commun, 2020 Aug 6. PMID 32517870
    4. Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress. Maillo C, et al. Nat Cell Biol, 2017 Feb. PMID 28092655
    5. Cpeb4-mediated translational regulatory circuitry controls terminal erythroid differentiation. Hu W, et al. Dev Cell, 2014 Sep 29. PMID 25220394, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
      Title: CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
    2. Restoration of CPEB4 prevents muscle stem cell senescence during aging.
      Title: Restoration of CPEB4 prevents muscle stem cell senescence during aging.
    3. Pathogenic Mis-splicing of CPEB4 in Schizophrenia.
      Title: Pathogenic Mis-splicing of CPEB4 in Schizophrenia.
    4. mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway.
      Title: mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway.
    5. CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
      Title: CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
    6. The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation.
      Title: The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation.
    7. Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
      Title: Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
    8. that cytoplasmic polyadenylation element-binding protein 4 (CPEB4) acts as a survival factor exclusively for early postnatal granule cells
      Title: Olfactory-Experience- and Developmental-Stage-Dependent Control of CPEB4 Regulates c-Fos mRNA Translation for Granule Cell Survival.
    9. Results show that Cpeb4 is highly expressed in the nervous system including spinal motor neurons. the CPEB4-unstructured low complexity domains (LCD) impairs neuron development that results in reduced motor axon branching and diminished NMJ formation in embryos and uncoordinated movement in neonatal mice.
      Title: Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration.
    10. combined transcriptional and translational Cpeb4 regulation generates a 'circadian mediator', which coordinates hepatic UPR activity with periods of high ER-protein-folding demand
      Title: Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA1673, 4930447D24Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA regulatory element binding translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation factor activity, RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to decreased oxygen levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ionotropic glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ischemia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of messenger ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytoplasmic polyadenylation element-binding protein 4
    Names
    CPE-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290676.1 → NP_001277605.1  cytoplasmic polyadenylation element-binding protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AI845839, AK162101, BC079599, CD803291
      UniProtKB/TrEMBL
      Q3TSF0
      Conserved Domains (3) summary
      cd12724
      Location:464 → 555
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:572 → 652
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:647 → 708
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

    2. NM_001290678.1 → NP_001277607.1  cytoplasmic polyadenylation element-binding protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001277607.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AI845839, AK162101, BC079599, CD803291
      UniProtKB/Swiss-Prot
      Q7TN98
      UniProtKB/TrEMBL
      Q3TSF0
      Conserved Domains (3) summary
      cd12724
      Location:447 → 538
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:555 → 635
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:630 → 691
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

    3. NM_026252.4 → NP_080528.2  cytoplasmic polyadenylation element-binding protein 4 isoform 1

      See identical proteins and their annotated locations for NP_080528.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI845839, AK162101, BC079599, CF182456
      Consensus CDS
      CCDS24514.1
      UniProtKB/Swiss-Prot
      A6H6G0, Q69ZD7, Q7TN98
      Related
      ENSMUSP00000020543.7, ENSMUST00000020543.13
      Conserved Domains (3) summary
      cd12724
      Location:472 → 563
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:580 → 660
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:655 → 716
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      31820911..31885635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514793.3 → XP_006514856.1  cytoplasmic polyadenylation element-binding protein 4 isoform X1

      UniProtKB/TrEMBL
      Q5SU48
      Related
      ENSMUSP00000105039.3, ENSMUST00000109412.9
      Conserved Domains (3) summary
      cd12724
      Location:455 → 546
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:563 → 643
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:638 → 699
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN98.1 GenPept UniProtKB/Swiss-Prot:Q7TN98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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