Sh2b3 SH2B adaptor protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh2b3provided by RGD
Official Full Name: SH2B adaptor protein 3provided by RGD
Primary source: RGD:68411
See related: Ensembl:ENSRNOG00000028198 AllianceGenome:RGD:68411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lnk
Summary: Enables phosphate ion binding activity. Involved in negative regulation of sprouting angiogenesis and regulation of regulatory T cell differentiation. Predicted to be active in plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in essential thrombocythemia; familial erythrocytosis 1; and myelofibrosis. Orthologous to human SH2B3 (SH2B adaptor protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 324.0), Lung (RPKM 268.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (40391755..40414336)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (34731934..34753617)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (40261990..40265757)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-29b upregulation improves myocardial fibrosis and cardiac function in myocardial infarction rats through targeting SH2B3.
Title: MicroRNA-29b upregulation improves myocardial fibrosis and cardiac function in myocardial infarction rats through targeting SH2B3.
These data demonstrate for the first time that SH2B3 is a crucial mediator of post-MI inflammation and fibrosis.
Title: SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.
SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure.
Title: Exacerbating Pressure Overload-Induced Cardiac Hypertrophy: Novel Role of Adaptor Molecule Src Homology 2-B3.
The resulting mutation was a 6-bp, in-frame deletion within a highly conserved region of the Src homology 2 (SH2) domain of SH2B3. This mutation significantly attenuated Dahl SS hypertension and renal disease.
Title: Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.
SH2B3 inhibits neuronal differentiation of PC12 cells and primary cortical neurons
Title: The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphate ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables stem cell factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within_negative_effect cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-3	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in megakaryocyte development	ISO Inferred from Sequence Orthology more info
involved_in monocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Kit signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil homeostasis	ISO Inferred from Sequence Orthology more info
involved_in regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect thrombopoietin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect thrombopoietin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in thrombopoietin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SH2B adapter protein 3

Names: linker of T-cell receptor pathways; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; signal transduction protein Lnk

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402348.1 → NP_001389277.1 SH2B adapter protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6J1C6, A6J1C7, D4ABY6

Related

ENSRNOP00000038125.4, ENSRNOT00000030583.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

40391755..40414336

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271604.1 → XP_063127674.1 SH2B adapter protein 3 isoform X1

UniProtKB/TrEMBL

A6J1C6, A6J1C7, D4ABY6
XM_063271603.1 → XP_063127673.1 SH2B adapter protein 3 isoform X1

UniProtKB/TrEMBL

A6J1C6, A6J1C7, D4ABY6
XM_063271605.1 → XP_063127675.1 SH2B adapter protein 3 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_031621.2: Suppressed sequence

Description

NM_031621.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.