Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ros1provided by RGD
Full Name: ROS proto-oncogene 1 , receptor tyrosine kinaseprovided by RGD
Primary source: RGD:3591
See related: Ensembl:ENSRNOG00000000406 AllianceGenome:RGD:3591
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ROS1C
Summary: Predicted to enable protein phosphatase binding activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including columnar/cuboidal epithelial cell development; positive regulation of kinase activity; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; and regulation of phosphate transport. Predicted to be located in cell surface and perinuclear region of cytoplasm. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 105.7), Kidney (RPKM 82.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (31975328..32126675, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (31432636..31583998, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (33100190..33323544, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uric acid plays an important role in CVD pathogenesis by inducing inflammatory COX-2 and ROS pathways. This is the first study demonstrating losartan's ability to reduce uric-acid-induced COX-2 elevation.
Title: Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells.
We identified novel cell surface markers specific for hepatic progenitor/oval cells. Six are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp).
Title: Novel hepatic progenitor cell surface markers in the adult rat liver.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94708 (e-PCR)
- UniSTS:119955

RH94709 (e-PCR)
- UniSTS:119956

RH140879 (e-PCR)
- UniSTS:222895

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in columnar/cuboidal epithelial cell development	IEA Inferred from Electronic Annotation more info
involved_in columnar/cuboidal epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in columnar/cuboidal epithelial cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phosphate transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proto-oncogene tyrosine-protein kinase ROS

Names: Ros1 proto-oncogene; c-Ros receptor tyrosine kinase; c-ros oncogene 1 , receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; proto-oncogene c-Ros; proto-oncogene c-Ros-1; proto-oncogene tyrosine-protein kinase ROS-like; receptor tyrosine kinase c-ros oncogene 1; v-ros UR2 sarcoma virus oncogene homolog 1

NP_037006.1

EC 2.7.10.1

XP_008771084.1

EC 2.7.10.1

XP_038954373.1

EC 2.7.10.1

XP_038954375.1

EC 2.7.10.1

XP_063135044.1

EC 2.7.10.1

XP_063135045.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012874.1 → NP_037006.1 proto-oncogene tyrosine-protein kinase ROS precursor

See identical proteins and their annotated locations for NP_037006.1

Status: PROVISIONAL

Source sequence(s)

M35106

UniProtKB/Swiss-Prot

Q63130, Q63131, Q63132

UniProtKB/TrEMBL

A0A8L2UH45, A6K478

Related

ENSRNOP00000000459.6, ENSRNOT00000000459.6

Conserved Domains (4) summary

smart00219
Location:1947 → 2207

TyrKc; Tyrosine kinase, catalytic domain

smart00060
Location:1448 → 1526

FN3; Fibronectin type 3 domain

cd00063
Location:211 → 290

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05044
Location:1947 → 2208

PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

31975328..32126675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772862.4 → XP_008771084.1 proto-oncogene tyrosine-protein kinase ROS isoform X3

See identical proteins and their annotated locations for XP_008771084.1

UniProtKB/TrEMBL

A0A8L2UH45, A6K476

Conserved Domains (4) summary

smart00219
Location:1926 → 2186

TyrKc; Tyrosine kinase, catalytic domain

smart00060
Location:1427 → 1505

FN3; Fibronectin type 3 domain

cd00063
Location:211 → 290

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05044
Location:1926 → 2187

PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
XM_039098447.2 → XP_038954375.1 proto-oncogene tyrosine-protein kinase ROS isoform X2

UniProtKB/TrEMBL

A0A8L2UH45

Conserved Domains (3) summary

smart00060
Location:111 → 178

FN3; Fibronectin type 3 domain

cd00063
Location:211 → 290

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05044
Location:1927 → 2188

PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
XM_039098445.2 → XP_038954373.1 proto-oncogene tyrosine-protein kinase ROS isoform X1

UniProtKB/TrEMBL

A0A8L2UH45, A0A8L2UPK7

Related

ENSRNOP00000068996.2

Conserved Domains (3) summary

smart00060
Location:111 → 178

FN3; Fibronectin type 3 domain

cd00063
Location:211 → 290

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05044
Location:1948 → 2209

PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
XM_063278975.1 → XP_063135045.1 proto-oncogene tyrosine-protein kinase ROS isoform X5
XM_063278974.1 → XP_063135044.1 proto-oncogene tyrosine-protein kinase ROS isoform X4

UniProtKB/TrEMBL

A0A8L2UH45