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    Slc7a6os solute carrier family 7, member 6 opposite strand [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246187, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc7a6osprovided by RGD
    Official Full Name
    solute carrier family 7, member 6 opposite strandprovided by RGD
    Primary source
    RGD:708394
    See related
    Ensembl:ENSRNOG00000020049 AllianceGenome:RGD:708394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in developmental process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to human SLC7A6OS (solute carrier family 7 member 6 opposite strand). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 114.3), Brain (RPKM 97.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc7a6os in Genome Data Viewer
    Location:
    19q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (51011850..51020514, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (34101978..34110666, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38180859..38189523, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group XV Neighboring gene solute carrier family 7 member 6 Neighboring gene protein arginine methyltransferase 7 Neighboring gene sphingomyelin phosphodiesterase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable RNA polymerase II nuclear localization protein SLC7A6OS

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139328.2 → NP_647544.2  probable RNA polymerase II nuclear localization protein SLC7A6OS

      See identical proteins and their annotated locations for NP_647544.2

      Status: VALIDATED

      Source sequence(s)
      AY098917, BM386170, DY567141
      UniProtKB/TrEMBL
      A6IYW4, G3V8N8
      Related
      ENSRNOP00000027200.4, ENSRNOT00000027200.6
      Conserved Domains (1) summary
      pfam08574
      Location:190 → 254
      DUF1762; Protein of unknown function (DUF1762)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      51011850..51020514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097474.2 → XP_038953402.1  probable RNA polymerase II nuclear localization protein SLC7A6OS isoform X1

    2. XM_039097475.2 → XP_038953403.1  probable RNA polymerase II nuclear localization protein SLC7A6OS isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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