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    Nob1 NIN1 (RPN12) binding protein 1 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291996, updated on 2-May-2024

    Summary

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    Official Symbol
    Nob1provided by RGD
    Official Full Name
    NIN1 (RPN12) binding protein 1 homologprovided by RGD
    Primary source
    RGD:735222
    See related
    Ensembl:ENSRNOG00000021890 AllianceGenome:RGD:735222
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nob1p
    Summary
    Predicted to enable endoribonuclease activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to act upstream of or within visual perception. Predicted to be located in nucleus. Predicted to be part of preribosome, small subunit precursor. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 95.7), Kidney (RPKM 80.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nob1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (52232543..52245824, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (35322803..35335354, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38397466..38409924)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T-cells 5 Neighboring gene uncharacterized LOC134483351 Neighboring gene NAD(P)H quinone dehydrogenase 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene eukaryotic translation initiation factor 5B, pseudogene 1 Neighboring gene microRNA 140

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of Nob1 in the rat auditory system with noise-induced hearing loss. Han Y, et al. Neurosci Lett, 2011 Mar 10. PMID 21219967
    2. Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA. Preti M, et al. Nucleic Acids Res, 2013 Apr. PMID 23482395, Free PMC Article
    3. Nob1p is required for cleavage of the 3' end of 18S rRNA. Fatica A, et al. Mol Cell Biol, 2003 Mar. PMID 12588997, Free PMC Article
    4. Rod-driven OFF pathway responses in the distal retina: dark-adapted flicker electroretinogram in mouse. Lei B. PLoS One, 2012. PMID 22937111, Free PMC Article
    5. Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing. Sloan KE, et al. J Cell Biol, 2013 Mar 4. PMID 23439679, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nob1 may play an important role in auditory function following acoustic trauma.
      Title: Up-regulation of Nob1 in the rat auditory system with noise-induced hearing loss.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156557

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein NOB1
    Names
    NIN1/PSMD8 binding protein 1 homolog
    nin one binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199086.1 → NP_954517.1  RNA-binding protein NOB1

      See identical proteins and their annotated locations for NP_954517.1

      Status: PROVISIONAL

      Source sequence(s)
      AY341886
      UniProtKB/Swiss-Prot
      A0JN09, Q6VEU1
      UniProtKB/TrEMBL
      A0A8L2UKR4, A6IZ01
      Related
      ENSRNOP00000031905.4, ENSRNOT00000034386.5
      Conserved Domains (4) summary
      cd09876
      Location:7 → 115
      PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
      COG1439
      Location:8 → 299
      Nob1; rRNA maturation endonuclease Nob1 [Translation, ribosomal structure and biogenesis]
      pfam15017
      Location:135 → 218
      AF1Q; Drug resistance and apoptosis regulator
      pfam08772
      Location:258 → 330
      NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      52232543..52245824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277929.1 → XP_063133999.1  RNA-binding protein NOB1 isoform X2

    2. XM_063277928.1 → XP_063133998.1  RNA-binding protein NOB1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6VEU1.1 GenPept UniProtKB/Swiss-Prot:Q6VEU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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