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    hcp1 protein secretion apparatus assembly protein [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879446, updated on 6-Oct-2023

    Summary

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    Gene symbol
    hcp1
    Gene description
    protein secretion apparatus assembly protein
    Primary source
    PseudoCap:PA0085
    Locus tag
    PA0085
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (103350..103838)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetically encoded photochemical covalent crosslinking within the Hcp-1 self-assembling bacterial secretion machinery. Antonczak AK, et al. Amino Acids, 2018 May. PMID 29307074
    2. Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates. Silverman JM, et al. Mol Cell, 2013 Sep 12. PMID 23954347, Free PMC Article
    3. Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins. Hachani A, et al. J Biol Chem, 2011 Apr 8. PMID 21325275, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results demonstrate the choice and role of genetically encoded tools applied to complicated biological processes such as self-assembly and also suggested some structural dynamics of the Hcp-1 protein not obvious from crystallographic structures.
      Title: Genetically encoded photochemical covalent crosslinking within the Hcp-1 self-assembling bacterial secretion machinery.
    2. Hcp1 protein is an exported receptor and chaperone of type VI bacterial secretion substrates.Hcp1 is a chaperone required for the intracellular accumulation of Tse2.
      Title: Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates.
    3. Hcp1 secretion requires either VgrG1a or VgrG1c, which may act independently to puncture the bacterial envelope and give Hcp1 access to the surface.
      Title: Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins.
    4. current data indicating that the HSI-I locus actively secretes Hcp1 during chronic infection of CF patients, collectively suggest a role for HSI-I in chronic P. aeruginosa infections
      Title: A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    protein secretion apparatus assembly protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      103350..103838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_248775.1 protein secretion apparatus assembly protein [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_248775.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2R3IPV7
      Conserved Domains (1) summary
      pfam05638
      Location:6 → 136
      T6SS_HCP; Type VI secretion system effector, Hcp
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I747.1

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