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    hemO heme oxygenase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 880820, updated on 24-Sep-2023

    Summary

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    Gene symbol
    hemO
    Gene description
    heme oxygenase
    Locus tag
    PA0672
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (732959..733555)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene error-prone DNA polymerase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ECF sigma factor VreI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The heme-binding protein PhuS transcriptionally regulates the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus. Wilson T, et al. J Biol Chem, 2021 Jan-Jun. PMID 33428928, Free PMC Article
    2. Biochemical characterization of biliverdins IXβ/δ generated by a selective heme oxygenase. Zhang B, et al. Biochem J, 2020 Feb 14. PMID 31913441
    3. Ligand-induced allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase. Deredge DJ, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28289188, Free PMC Article
    4. Metabolite-driven Regulation of Heme Uptake by the Biliverdin IXβ/δ-Selective Heme Oxygenase (HemO) of Pseudomonas aeruginosa. Mouriño S, et al. J Biol Chem, 2016 Sep 23. PMID 27493207, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The heme-binding protein PhuS transcriptionally regulates the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus.
      Title: The heme-binding protein PhuS transcriptionally regulates the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus.
    2. Authors exploited the unique capacity of the Pseudomonas aeruginosa hemO/pigA gene for focused generation of isomeric biliverdinss (IXbeta and IXdelta).
      Title: Biochemical characterization of biliverdins IXβ/δ generated by a selective heme oxygenase.
    3. The PhuS N-terminal alpha1/alpha2-helices that are cooperatively linked to the motions of the C-terminal domain also map to the PhuS:HemO interface.
      Title: Ligand-induced allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase.
    4. coupling the PhuS-dependent flux of heme through HemO to feedback regulation of the cell surface signaling system through HasA allows P. aeruginosa to rapidly respond to fluctuating extracellular heme levels independent of the iron status of the cell.
      Title: Metabolite-driven Regulation of Heme Uptake by the Biliverdin IXβ/δ-Selective Heme Oxygenase (HemO) of Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within heme oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heme oxygenase
    NP_249363.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      732959..733555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249363.1 heme oxygenase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249363.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G3XCZ8, O69002
      Conserved Domains (2) summary
      COG3230
      Location:4 → 198
      HemO; Heme oxygenase [Inorganic ion transport and metabolism]
      cd00232
      Location:110 → 135
      HemeO-like; kinked helix [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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