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    Apol3l1 apolipoprotein L3 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315108, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Apol3l1provided by RGD
    Official Full Name
    apolipoprotein L3 like 1provided by RGD
    Primary source
    RGD:1306480
    See related
    Ensembl:ENSRNOG00000042771 AllianceGenome:RGD:1306480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Apol3
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and schizophrenia. Orthologous to several human genes including APOL3 (apolipoprotein L3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 406.9), Liver (RPKM 398.9) and 9 other tissues See more
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    Genomic context

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    See Apol3l1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111169307..111178306)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109288725..109297728)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (118685022..118694016)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein L11a Neighboring gene uncharacterized LOC134479936 Neighboring gene uncharacterized LOC102552424 Neighboring gene apolipoprotein L7b like 1 Neighboring gene apolipoprotein L2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein L, 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013175.3 → NP_001013193.1  apolipoprotein L, 3

      See identical proteins and their annotated locations for NP_001013193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HSG3, Q5U1W1
      Related
      ENSRNOP00000075710.1, ENSRNOT00000089135.2
      Conserved Domains (1) summary
      pfam05461
      Location:35 → 332
      ApoL; Apolipoprotein L

    2. NM_001277359.3 → NP_001264288.1  apolipoprotein L, 3

      See identical proteins and their annotated locations for NP_001264288.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HSG3, Q5U1W1
      Conserved Domains (1) summary
      pfam05461
      Location:35 → 332
      ApoL; Apolipoprotein L

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      111169307..111178306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079252.2 → XP_038935180.1  apolipoprotein L, 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP14
      Conserved Domains (1) summary
      pfam05461
      Location:3 → 286
      ApoL; Apolipoprotein L
    Nucleotide Protein Strain
    Heading Accession and Version

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