Prelid1 PRELI domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prelid1provided by MGI
Official Full Name: PRELI domain containing 1provided by MGI
Primary source: MGI:MGI:1913744
See related: Ensembl:ENSMUSG00000021486 AllianceGenome:MGI:1913744
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Preli; 2610524G07Rik
Summary: Predicted to enable phosphatidic acid transfer activity. Involved in negative regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including brain; gonad; immune system; liver; and stomach. Orthologous to human PRELID1 (PRELI domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 465.5), large intestine adult (RPKM 374.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 29.8 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (55469868..55473085)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (55322055..55325272)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRELI is a vital LEA B cell protein with failsafe genetics
Title: Spare PRELI gene loci: failsafe chromosome insurance?
PRELI interacts with OPA1 to maintain mitochondria structures intact, sustain balanced ion(-)/proton(+) gradients, promote oxidative phosphorylation reactions, regulate pro- and antiapoptotic protein traffic and enable cell responses to induced death.
Title: Vital function of PRELI and essential requirement of its LEA motif.
Identification of PRELI (protein of relevant evolutionary and lymphoid interest) which encodes a mitochondrial protein and is located on a conserved gene cluster on chromosome 5.
Title: PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidic acid transfer activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to phosphatidic acid transfer activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in phospholipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane lipid distribution	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PRELI domain-containing protein 1, mitochondrial

Names: PX19 homolog; protein of relevant evolutionary and lymphoid interest; px19-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.