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    Endov endonuclease V [ Mus musculus (house mouse) ]

    Gene ID: 338371, updated on 12-May-2024

    Summary

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    Official Symbol
    Endovprovided by MGI
    Official Full Name
    endonuclease Vprovided by MGI
    Primary source
    MGI:MGI:2444688
    See related
    Ensembl:ENSMUSG00000039850 AllianceGenome:MGI:2444688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730011L01Rik
    Summary
    Enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters and magnesium ion binding activity. Involved in DNA repair. Predicted to be located in cytoplasmic stress granule. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ENDOV (endonuclease V). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 5.4), limb E14.5 (RPKM 5.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Endov in Genome Data Viewer
    Location:
    11 E2; 11 83.8 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119382173..119402291)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119491322..119511465)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 1932 Neighboring gene ring finger protein 213 Neighboring gene STARR-positive B cell enhancer ABC_E3043 Neighboring gene RIKEN cDNA A930037H05 gene Neighboring gene STARR-positive B cell enhancer ABC_E7112 Neighboring gene STARR-positive B cell enhancer ABC_E8475 Neighboring gene predicted gene, 39484 Neighboring gene neuronal pentraxin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma. Kong XY, et al. Nucleic Acids Res, 2020 May 7. PMID 32083667, Free PMC Article
    2. Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease. Nawaz MS, et al. Sci Rep, 2016 Apr 25. PMID 27108838, Free PMC Article
    3. Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V. Moe A, et al. Nucleic Acids Res, 2003 Jul 15. PMID 12853604, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest that EndoV is involved in the development of hepatocellular carcinoma in mice.
      Title: Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
    2. Mouse Endonuclease V shares substrate preferences with human EndoV by catalyzing cleavage at inosines in RNA and being inert towards inosines in DNA.
      Title: Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity, producing 5'-phosphomonoesters IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity, producing 5'-phosphomonoesters ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease V
    Names
    novel endonuclease V protein
    putative endonuclease FLJ39025 homolog
    NP_001158108.1
    NP_001388988.1
    NP_001388989.1
    NP_796368.1
    XP_011247389.1
    XP_036012680.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164636.1 → NP_001158108.1  endonuclease V isoform 1

      See identical proteins and their annotated locations for NP_001158108.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK084233, AL645911, BC056486
      Consensus CDS
      CCDS48999.1
      UniProtKB/Swiss-Prot
      B1ATE4, Q3TCQ4, Q8C3Y1, Q8C9A2
      Related
      ENSMUSP00000101851.3, ENSMUST00000106244.9
      Conserved Domains (1) summary
      cd06559
      Location:17 → 245
      Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

    2. NM_001402059.1 → NP_001388988.1  endonuclease V isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645911

    3. NM_001402060.1 → NP_001388989.1  endonuclease V isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645911

    4. NM_177394.3 → NP_796368.1  endonuclease V isoform 2

      See identical proteins and their annotated locations for NP_796368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents an alternate 5' splice pattern and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL645911, BC056486, BY266398
      Consensus CDS
      CCDS25718.1
      UniProtKB/Swiss-Prot
      Q8C9A2
      Related
      ENSMUSP00000132755.2, ENSMUST00000106245.9
      Conserved Domains (1) summary
      cd06559
      Location:7 → 162
      Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

    RNA

    1. NR_174994.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645911
      Related
      ENSMUST00000143817.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119382173..119402291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249087.3 → XP_011247389.1  endonuclease V isoform X4

      Conserved Domains (1) summary
      cd06559
      Location:17 → 245
      Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

    2. XM_036156787.1 → XP_036012680.1  endonuclease V isoform X1

      Conserved Domains (1) summary
      cd06559
      Location:17 → 245
      Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

    RNA

    1. XR_004936981.1 RNA Sequence

    2. XR_388482.4 RNA Sequence

    3. XR_004936983.1 RNA Sequence

    4. XR_004936982.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C9A2.2 GenPept UniProtKB/Swiss-Prot:Q8C9A2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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