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    VAC17 Vac17p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850296, updated on 13-Apr-2024

    Summary

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    Gene symbol
    VAC17
    Gene description
    Vac17p
    Primary source
    SGD:S000000568
    Locus tag
    YCL063W
    See related
    AllianceGenome:SGD:S000000568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YCL062W
    Summary
    Enables protein-membrane adaptor activity. Involved in vacuole inheritance. Located in fungal-type vacuole membrane. Part of Myo2p-Vac17p-Vac8p transport complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (17290..18561)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene transcriptional co-activator mating type protein alpha Neighboring gene L-serine/L-threonine ammonia-lyase CHA1 Neighboring gene chromatin-modulating protein MRC1 Neighboring gene ribosome biosynthesis protein KRR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Organelle Size Scaling of the Budding Yeast Vacuole by Relative Growth and Inheritance. Chan YH, et al. Curr Biol, 2016 May 9. PMID 27151661, Free PMC Article
    2. Increasing population growth by asymmetric segregation of a limiting resource during cell division. Avraham N, et al. Mol Syst Biol, 2013 Apr 16. PMID 23591772, Free PMC Article
    3. Identification of an organelle-specific myosin V receptor. Ishikawa K, et al. J Cell Biol, 2003 Mar 17. PMID 12642614, Free PMC Article
    4. Spatial regulation of organelle release from myosin V transport by p21-activated kinases. Yau RG, et al. J Cell Biol, 2017 Jun 5. PMID 28495836, Free PMC Article
    5. The cyclin-dependent kinase Cdk1 directly regulates vacuole inheritance. Peng Y, et al. Dev Cell, 2008 Sep. PMID 18804442, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-membrane adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in vacuole inheritance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuole inheritance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vacuole inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole inheritance IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Myo2p-Vac17p-Vac8p transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vac17p
    NP_009870.1
    • Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p; involved in regulation of asymmetric inheritance of aggregated/misfolded proteins and age reset

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      17290..18561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178705.1 → NP_009870.1  TPA: Vac17p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009870.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQV5, P25590, P25591
      UniProtKB/TrEMBL
      A0A8H4BTN9, A6ZTD4, B3LU23, B5VEP9, N1P804
      Conserved Domains (1) summary
      pfam17321
      Location:6 → 422
      Vac17; Vacuole-related protein 17
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25591.2

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