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    Igsf1 immunoglobulin superfamily, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302822, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Igsf1provided by RGD
    Official Full Name
    immunoglobulin superfamily, member 1provided by RGD
    Primary source
    RGD:631402
    See related
    Ensembl:ENSRNOG00000007600 AllianceGenome:RGD:631402
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Inhbp
    Summary
    Enables coreceptor activity. Predicted to be involved in negative regulation of activin receptor signaling pathway and regulation of transcription, DNA-templated. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in IGSF1 deficiency syndrome. Orthologous to human IGSF1 (immunoglobulin superfamily member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 103.3), Adrenal (RPKM 69.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Igsf1 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (133947717..133963154, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (129069891..129085331, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (136792637..136808107, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily Q member 2 Neighboring gene olfactory receptor family 5 subfamily O member 1 Neighboring gene olfactory receptor family 11 subfamily N member 2 Neighboring gene olfactory receptor family 5 subfamily BH member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spatial and temporal expression of immunoglobulin superfamily member 1 in the rat. Joustra SD, et al. J Endocrinol, 2015 Sep. PMID 26163525
    2. Inhibin binding protein in rats: alternative transcripts and regulation in the pituitary across the estrous cycle. Bernard DJ, et al. Mol Endocrinol, 2001 Apr. PMID 11266515
    3. The short mRNA isoform of the immunoglobulin superfamily, member 1 gene encodes an intracellular glycoprotein. Wang Y, et al. PLoS One, 2017. PMID 28686733, Free PMC Article
    4. Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). Chapman SC, et al. Mol Endocrinol, 2001 Apr. PMID 11266516
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156568

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables activin receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables activin receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inhibin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inhibin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of activin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily member 1
    Names
    inhibin-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175763.2 → NP_786939.1  immunoglobulin superfamily member 1 precursor

      See identical proteins and their annotated locations for NP_786939.1

      Status: PROVISIONAL

      Source sequence(s)
      AF322216
      UniProtKB/Swiss-Prot
      A0JPK8, Q925N5, Q925N6
      UniProtKB/TrEMBL
      A0A8L2Q5H1, A6JMS1
      Related
      ENSRNOP00000010325.5, ENSRNOT00000010325.6
      Conserved Domains (2) summary
      smart00410
      Location:772 → 852
      IG_like; Immunoglobulin like
      cl11960
      Location:1145 → 1231
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      133947717..133963154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279962.1 → XP_063136032.1  immunoglobulin superfamily member 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2Q5H1

    2. XM_063279959.1 → XP_063136029.1  immunoglobulin superfamily member 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q5H1

    3. XM_063279960.1 → XP_063136030.1  immunoglobulin superfamily member 1 isoform X3

      UniProtKB/Swiss-Prot
      A0JPK8, Q925N5, Q925N6
      UniProtKB/TrEMBL
      A0A8L2Q5H1, A6JMS1

    4. XM_006257557.4 → XP_006257619.1  immunoglobulin superfamily member 1 isoform X1

      See identical proteins and their annotated locations for XP_006257619.1

      UniProtKB/TrEMBL
      A0A8L2Q5H1
      Conserved Domains (2) summary
      smart00410
      Location:781 → 861
      IG_like; Immunoglobulin like
      cl11960
      Location:1154 → 1240
      Ig; Immunoglobulin domain

    5. XM_063279965.1 → XP_063136035.1  immunoglobulin superfamily member 1 isoform X10

      UniProtKB/TrEMBL
      A0A8L2Q5H1

    6. XM_006257561.3 → XP_006257623.1  immunoglobulin superfamily member 1 isoform X9

      UniProtKB/TrEMBL
      A0A8L2Q5H1
      Conserved Domains (2) summary
      smart00410
      Location:781 → 861
      IG_like; Immunoglobulin like
      cl11960
      Location:1058 → 1144
      Ig; Immunoglobulin domain

    7. XM_063279961.1 → XP_063136031.1  immunoglobulin superfamily member 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2Q5H1

    8. XM_006257558.3 → XP_006257620.1  immunoglobulin superfamily member 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q5H1
      Conserved Domains (2) summary
      smart00410
      Location:780 → 860
      IG_like; Immunoglobulin like
      cl11960
      Location:1153 → 1239
      Ig; Immunoglobulin domain

    9. XM_063279963.1 → XP_063136033.1  immunoglobulin superfamily member 1 isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q5H1

    10. XM_063279964.1 → XP_063136034.1  immunoglobulin superfamily member 1 isoform X8

      UniProtKB/TrEMBL
      A0A8L2Q5H1

    11. XM_006257559.3 → XP_006257621.1  immunoglobulin superfamily member 1 isoform X5

      UniProtKB/TrEMBL
      A0A8L2Q5H1
      Conserved Domains (2) summary
      smart00410
      Location:752 → 832
      IG_like; Immunoglobulin like
      cl11960
      Location:1125 → 1211
      Ig; Immunoglobulin domain

    12. XM_006257560.3 → XP_006257622.1  immunoglobulin superfamily member 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6ATC3, A0A8L2Q5H1
      Related
      ENSRNOP00000097633.1
      Conserved Domains (2) summary
      smart00410
      Location:781 → 861
      IG_like; Immunoglobulin like
      cl11960
      Location:1154 → 1240
      Ig; Immunoglobulin domain

    13. XM_008773563.3 → XP_008771785.1  immunoglobulin superfamily member 1 isoform X1

      See identical proteins and their annotated locations for XP_008771785.1

      UniProtKB/TrEMBL
      A0A8L2Q5H1
      Conserved Domains (2) summary
      smart00410
      Location:781 → 861
      IG_like; Immunoglobulin like
      cl11960
      Location:1154 → 1240
      Ig; Immunoglobulin domain

    14. XM_039099678.1 → XP_038955606.1  immunoglobulin superfamily member 1 isoform X11

      UniProtKB/TrEMBL
      A6JMS3
      Conserved Domains (2) summary
      cd00096
      Location:122 → 128
      Ig; Ig strand A [structural motif]
      cl11960
      Location:121 → 211
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925N6.1 GenPept UniProtKB/Swiss-Prot:Q925N6

    Gene LinkOut

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