Septin7 septin 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Septin7provided by RGD
Official Full Name: septin 7provided by RGD
Primary source: RGD:620469
See related: Ensembl:ENSRNOG00000006545 AllianceGenome:RGD:620469
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cdc10; Sept7
Summary: Predicted to enable GTPase activity; identical protein binding activity; and molecular adaptor activity. Involved in postsynapse organization. Located in membrane. Is active in glutamatergic synapse. Orthologous to human SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 1102.5), Heart (RPKM 763.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (31995597..32059069)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (23719448..23783247)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (26412910..26476615)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

show that diffusion of receptors and bulk membrane, but not cytoplasmic proteins, is slower in spines bearing Sept7 at their neck. Finally, when Sept7 expression was suppressed by RNA interference, membrane molecules explored larger membrane areas. Our findings indicate that Sept7 regulates membrane protein access to spines
Title: A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks.
The data indicate that septin 7 hinders GLUT4 storage vesicle trafficking and further, the interaction of septin 7 with nephrin in glomeruli suggests that septin 7 may participate in the regulation of glucose transport in podocytes.
Title: Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.
Knockdown of SEPT5 or SEPT7 in developing hippocampal neurons impaired axon growth.
Title: Characterization of presynaptic septin complexes in mammalian hippocampal neurons.
localizes at the bases of filopodia and at branch points in developing hippocampal neurons
Title: The GTP-binding protein Septin 7 is critical for dendrite branching and dendritic-spine morphology.
Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption.
Title: Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483594

UniSTS:236081 (e-PCR)
- UniSTS:236081

Sept7 (e-PCR), detects polymorphism
- UniSTS:507215

CDC10_514 (e-PCR)
- UniSTS:277079

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of postsynapse	EXP Inferred from Experiment more info	PubMed
enables structural constituent of postsynapse	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within collateral sprouting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cortical cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pseudopodium retraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
is_active_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic septin cytoskeleton	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic septin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic septin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IEA Inferred from Electronic Annotation more info
part_of septin complex	ISO Inferred from Sequence Orthology more info
part_of septin complex	ISS Inferred from Sequence or Structural Similarity more info
located_in septin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in septin filament array	ISO Inferred from Sequence Orthology more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
located_in septin ring	ISO Inferred from Sequence Orthology more info
located_in sperm annulus	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: septin-7

Names: CDC10 (cell division cycle 10, S.cerevisiae, homolog); CDC10 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113740.1 → NP_001107212.1 septin-7 isoform b

See identical proteins and their annotated locations for NP_001107212.1

Status: VALIDATED

Source sequence(s)

BC128738, CA512303, EV764168

UniProtKB/Swiss-Prot

Q9WVC0

UniProtKB/TrEMBL

A2VCW8, D4A0F5

Related

ENSRNOP00000059464.4, ENSRNOT00000063967.4

Conserved Domains (2) summary

cd01850
Location:47 → 317

CDC_Septin; CDC/Septin GTPase family

PRK12704
Location:337 → 433

PRK12704; phosphodiesterase; Provisional
NM_022616.2 → NP_072138.2 septin-7 isoform a

See identical proteins and their annotated locations for NP_072138.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q9WVC0

Related

ENSRNOP00000008839.7, ENSRNOT00000008838.8

Conserved Domains (2) summary

cd01850
Location:46 → 316

CDC_Septin; CDC/Septin GTPase family

PRK12704
Location:336 → 432

PRK12704; phosphodiesterase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

31995597..32059069

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266076.1 → XP_063122146.1 septin-7 isoform X1

UniProtKB/TrEMBL

A6JYB9
XM_039082087.2 → XP_038938015.1 septin-7 isoform X1

UniProtKB/TrEMBL

A6JYB8, A6JYB9

Conserved Domains (2) summary

cd01850
Location:1 → 264

CDC_Septin; CDC/Septin GTPase family

PRK12704
Location:284 → 380

PRK12704; phosphodiesterase; Provisional
XM_063266077.1 → XP_063122147.1 septin-7 isoform X1

UniProtKB/TrEMBL

A6JYB9
XM_039082088.2 → XP_038938016.1 septin-7 isoform X2

Conserved Domains (2) summary

cd01850
Location:1 → 165

CDC_Septin; CDC/Septin GTPase family

PRK12704
Location:185 → 269

PRK12704; phosphodiesterase; Provisional