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    Arv1 ARV1 homolog, fatty acid homeostasis modulator [ Mus musculus (house mouse) ]

    Gene ID: 68865, updated on 12-May-2024

    Summary

    Official Symbol
    Arv1provided by MGI
    Official Full Name
    ARV1 homolog, fatty acid homeostasis modulatorprovided by MGI
    Primary source
    MGI:MGI:1916115
    See related
    Ensembl:ENSMUSG00000031982 AllianceGenome:MGI:1916115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110067L22Rik
    Summary
    Acts upstream of or within bile acid metabolic process and regulation of cholesterol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and cortical endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 38. Orthologous to human ARV1 (ARV1 homolog, fatty acid homeostasis modulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.0), ovary adult (RPKM 7.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Arv1 in Genome Data Viewer
    Location:
    8 E2; 8 72.81 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125448765..125469533)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124722026..124742794)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 13 Neighboring gene predicted gene, 46058 Neighboring gene predicted gene, 30273 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:127246145-127246328 Neighboring gene family with sequence similarity 89, member A Neighboring gene general transcription factor IIB pseudogene Neighboring gene predicted gene, 46059

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cortical endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368372.1NP_001355301.1  protein ARV1

      Status: VALIDATED

      Source sequence(s)
      AC151736
      Consensus CDS
      CCDS22774.1
      UniProtKB/Swiss-Prot
      Q8BY08, Q9D0U9
      UniProtKB/TrEMBL
      Q0VBH5
      Conserved Domains (1) summary
      pfam04161
      Location:28217
      Arv1; Arv1-like family
    2. NM_026855.5NP_081131.1  protein ARV1

      See identical proteins and their annotated locations for NP_081131.1

      Status: VALIDATED

      Source sequence(s)
      AC151736
      Consensus CDS
      CCDS22774.1
      UniProtKB/Swiss-Prot
      Q8BY08, Q9D0U9
      UniProtKB/TrEMBL
      Q0VBH5
      Related
      ENSMUSP00000034463.4, ENSMUST00000034463.4
      Conserved Domains (1) summary
      pfam04161
      Location:28217
      Arv1; Arv1-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      125448765..125469533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248496.3XP_011246798.1  protein ARV1 isoform X1

      See identical proteins and their annotated locations for XP_011246798.1

      UniProtKB/Swiss-Prot
      Q8BY08, Q9D0U9
      UniProtKB/TrEMBL
      Q0VBH5
      Conserved Domains (1) summary
      pfam04161
      Location:28217
      Arv1; Arv1-like family
    2. XM_006531337.4XP_006531400.1  protein ARV1 isoform X1

      See identical proteins and their annotated locations for XP_006531400.1

      UniProtKB/Swiss-Prot
      Q8BY08, Q9D0U9
      UniProtKB/TrEMBL
      Q0VBH5
      Conserved Domains (1) summary
      pfam04161
      Location:28217
      Arv1; Arv1-like family