Numa1 nuclear mitotic apparatus protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Numa1provided by MGI
Official Full Name: nuclear mitotic apparatus protein 1provided by MGI
Primary source: MGI:MGI:2443665
See related: Ensembl:ENSMUSG00000066306 AllianceGenome:MGI:2443665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NuMA; 6720401E04Rik
Summary: Predicted to enable several functions, including disordered domain specific binding activity; dynein complex binding activity; and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of BMP signaling pathway; and positive regulation of keratinocyte differentiation. Acts upstream of or within lung epithelial cell differentiation. Located in several cellular components, including lateral cell cortex; mitotic spindle pole; and nuclear matrix. Is expressed in lung epithelium; midbrain ventricular layer; olfactory lobe; pigmented retinal epithelium; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 20.3), ovary adult (RPKM 17.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.7 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (101583169..101664166)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (101933977..102014959)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developmental defects in Huntington's disease show that axonal growth and microtubule reorganization require NUMA1.
Title: Developmental defects in Huntington's disease show that axonal growth and microtubule reorganization require NUMA1.
It has been reported that the Galectin-3/NuMA interaction is functionally important for the spindle pole organization; spindle pole cohesion requires glycosylation-mediated localization of NuMA.
Title: Spindle pole cohesion requires glycosylation-mediated localization of NuMA.
siRNA-mediated depletion of NuMA induced abnormal mitotic phenotypes in cultured mouse embryonic fibroblasts and aberrant neurogenesis and neuronal migration in the mouse embryonic brain
Title: Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.
These results reveal an additional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative use of spindle orientation in the skin to build diverse structures.
Title: NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.
Suppressor APC domain containing 2 negatively regulates the localization of LGN at the cell cortex, likely by competing with NuMA for its binding
Title: SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.
Loss of 4.1/NuMA interaction results in spindle orientation defects and inhibition of Cdk1 causes increase in cortical NuMA localization
Title: NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions.
ectopic expression of BRAP2 inhibits nuclear localization of HMG20A and NuMA1, and prevents nuclear envelope accumulation of SYNE2.
Title: The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins.
Inhibiting Crm1 in early metaphase causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers.
Title: Inhibiting Crm1 causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers.
Thus, NuMA is a defining feature of the mammalian spindle pole and functions as an essential tether linking bulk microtubules of the spindle to centrosomes.
Title: Requirements for NuMA in maintenance and establishment of mammalian spindle poles.
Fusion protein NuMA-RARalpha cooperates with RXRalpha in the development of leukemia in hCG-NuMA-RARalpha transgenic mice.
Title: Evidence of functional interaction between NuMA-RARalpha and RXRalpha in an in vivo model of acute promyelocytic leukemia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU014979 (e-PCR)
- UniSTS:208166

RH125312 (e-PCR)
- UniSTS:162134

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule minus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anastral spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome separation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic spindle elongation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell cortex	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to spindle pole body	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of metaphase plate congression	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex region	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex region	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cortical microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic microtubule bundle	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in lateral cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule bundle	ISO Inferred from Sequence Orthology more info
located_in microtubule minus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle astral microtubule	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info	PubMed
located_in spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear mitotic apparatus protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403544.1 → NP_001390473.1 nuclear mitotic apparatus protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC167240
NM_001403545.1 → NP_001390474.1 nuclear mitotic apparatus protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC167240
NM_001403546.1 → NP_001390475.1 nuclear mitotic apparatus protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC167240
NM_001403547.1 → NP_001390476.1 nuclear mitotic apparatus protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC167240
NM_001403548.1 → NP_001390477.1 nuclear mitotic apparatus protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC167240
NM_001403549.1 → NP_001390478.1 nuclear mitotic apparatus protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC167240
NM_001403550.1 → NP_001390479.1 nuclear mitotic apparatus protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC167240
NM_001403551.1 → NP_001390480.1 nuclear mitotic apparatus protein 1 isoform b

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

E9Q7G0, Q80Y35
NM_001403552.1 → NP_001390481.1 nuclear mitotic apparatus protein 1 isoform c

Status: VALIDATED

Source sequence(s)

AC167240
NM_001403553.1 → NP_001390482.1 nuclear mitotic apparatus protein 1 isoform d

Status: VALIDATED

Source sequence(s)

AC167240
NM_133947.4 → NP_598708.3 nuclear mitotic apparatus protein 1 isoform b

See identical proteins and their annotated locations for NP_598708.3

Status: VALIDATED

Source sequence(s)

AC167240

Consensus CDS

CCDS40046.1

UniProtKB/Swiss-Prot

E9Q7G0, Q80Y35

Related

ENSMUSP00000081912.6, ENSMUST00000084852.13

Conserved Domains (4) summary

COG1196
Location:1117 → 1713

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:554 → 1323

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1852 → 1910

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

101583169..101664166

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507177.4 → XP_006507240.1 nuclear mitotic apparatus protein 1 isoform X2

See identical proteins and their annotated locations for XP_006507240.1

UniProtKB/Swiss-Prot

E9Q7G0, Q80Y35

Conserved Domains (4) summary

COG1196
Location:1117 → 1713

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:554 → 1323

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1852 → 1910

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_036152542.1 → XP_036008435.1 nuclear mitotic apparatus protein 1 isoform X2

UniProtKB/Swiss-Prot

E9Q7G0, Q80Y35

Conserved Domains (4) summary

COG1196
Location:1117 → 1713

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:554 → 1323

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1852 → 1910

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_036152544.1 → XP_036008437.1 nuclear mitotic apparatus protein 1 isoform X5

Conserved Domains (3) summary

TIGR02168
Location:462 → 1231

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22298
Location:1774 → 1832

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins

cl41774
Location:1 → 59

HkD_SF; Hook domain-containing proteins superfamily
XM_036152541.1 → XP_036008434.1 nuclear mitotic apparatus protein 1 isoform X2

UniProtKB/Swiss-Prot

E9Q7G0, Q80Y35

Conserved Domains (4) summary

COG1196
Location:1117 → 1713

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:554 → 1323

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1852 → 1910

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
XM_006507175.4 → XP_006507238.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_006507238.1

Conserved Domains (1) summary

TIGR02168
Location:554 → 1323

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036152540.1 → XP_036008433.1 nuclear mitotic apparatus protein 1 isoform X2

UniProtKB/Swiss-Prot

E9Q7G0, Q80Y35

Conserved Domains (4) summary

COG1196
Location:1117 → 1713

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:554 → 1323

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22224
Location:6 → 151

HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins

cd22298
Location:1852 → 1910

NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins