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Ccl5 C-C motif chemokine ligand 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81780, updated on 13-Apr-2024

Summary

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Official Symbol: Ccl5provided by RGD
Official Full Name: C-C motif chemokine ligand 5provided by RGD
Primary source: RGD:69069
See related: AllianceGenome:RGD:69069
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Scya5; Rantes
Summary: Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to organonitrogen compound; lymphocyte migration; and positive regulation of leukocyte chemotaxis. Located in extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; non-alcoholic fatty liver disease; and orchitis. Biomarker of several diseases, including alcoholic hepatitis; artery disease (multiple); cardiac arrest; lung disease (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 432.8), Lung (RPKM 349.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Ccl5 in Genome Data Viewer

Location:: 10q26

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (68820330..68824906, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (68322826..68327380, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (70739764..70744303, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion.
Title: Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion.
Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-kappaB Signaling Pathway.
Title: Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway.
Although modification of PMCAs composition could provide some protection against calcium overload, reduction of PMCA2 appeared to be more detrimental to the cells than deficiency of PMCA3. Under pathological conditions, including inflammatory CCL5 action and long-lasting Ca(2+) dyshomeostasis, insufficient cell protection may result in progressive degeneration and death of neurons.
Title: Calcium Dyshomeostasis Alters CCL5 Signaling in Differentiated PC12 Cells.
CCL5 plays a pivotal regulatory role in hepatic fibrosis during nonalcoholic fatty liver disease.
Title: Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress.
The inhibition of spinal CCL5 expression may provide a new method to prevent and treat nerve injury-induced neuropathic pain.
Title: Spinal NF-κB and chemokine ligand 5 expression during spinal glial cell activation in a neuropathic pain model.
study provides novel evidence that IL-10 plays an up-regulatory role in the anti-hypertensive activity of CCL5 in SHR VSMCs
Title: IL-10 up-regulates CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats.
Expression of RANTES and CCR5 in cardiac allografts may play important roles in chronic rejection.
Title: The significance for chronic rejection of cardiac allograft of regulated upon activation normal T-cell cytokine and its CCR5 receptor.
Mutants of RANTES/CCL5 may also represent an innovative approach to prevent the angiogenesis associated with the formation of atherosclerotic plaque
Title: RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans.
Control of transplant tolerance and intragraft regulatory T cell localization by myeloid-derived suppressor cells and CCL5.
Title: Control of transplant tolerance and intragraft regulatory T cell localization by myeloid-derived suppressor cells and CCL5.
CCL5 induction in aorta and smooth muscle cells is mediated by IRF-1 while activation of p38 MAPK signaling inhibits CCL5 and IP-10 expression.
Title: Regulation of CCL5 expression in smooth muscle cells following arterial injury.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

D10Chm184 (e-PCR)
- UniSTS:518179

Ccl5 (e-PCR), detects polymorphism
- UniSTS:530818

RH129414 (e-PCR)
- UniSTS:212721

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR1 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables CCR5 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper 1 cell diapedesis	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to alkyl hydroperoxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to amino acid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cytokine stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to high density lipoprotein particle stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to morphine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vitamin K	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in chronic inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
involved_in dibenzo-p-dioxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in eosinophil chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fever generation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in pseudopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C motif chemokine 5

Names: SIS-delta; T-cell-specific protein RANTES; chemokine (C-C motif) ligand 5; regulated upon activation normal T-cell expressed and secreted; small-inducible cytokine A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031116.4 → NP_112378.2 C-C motif chemokine 5 precursor

See identical proteins and their annotated locations for NP_112378.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A1EC65, A1ECA0, Q6PED1

Conserved Domains (1) summary

smart00199
Location:32 → 89

SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)