C1qtnf1 C1q and TNF related 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1qtnf1provided by RGD
Official Full Name: C1q and TNF related 1provided by RGD
Primary source: RGD:1359204
See related: Ensembl:ENSRNOG00000003259 AllianceGenome:RGD:1359204
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ctrp1
Summary: Predicted to enable collagen binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of platelet aggregation; positive regulation of aldosterone secretion; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within positive regulation of MAPK cascade; positive regulation of protein kinase B signaling; and regulation of glucose metabolic process. Predicted to be integral component of plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in extracellular space. Orthologous to human C1QTNF1 (C1q and TNF related 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 189.7), Lung (RPKM 62.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (104159021..104180253)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (103660319..103681662)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (107455845..107477160)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.[Ctrp1]
Title: Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aldosterone secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aldosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q tumor necrosis factor-related protein 1

Names: C1q and tumor necrosis factor related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007675.1 → NP_001007676.1 complement C1q tumor necrosis factor-related protein 1 precursor

See identical proteins and their annotated locations for NP_001007676.1

Status: PROVISIONAL

Source sequence(s)

BC083720

UniProtKB/Swiss-Prot

Q5XIG2

UniProtKB/TrEMBL

A0A0G2JXS9, A6HL59

Related

ENSRNOP00000070390.2, ENSRNOT00000087404.2

Conserved Domains (2) summary

pfam00386
Location:147 → 275

C1q; C1q domain

pfam01391
Location:98 → 138

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

104159021..104180253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269244.1 → XP_063125314.1 complement C1q tumor necrosis factor-related protein 1 isoform X1

UniProtKB/Swiss-Prot

Q5XIG2

UniProtKB/TrEMBL

A6HL59
XM_063269243.1 → XP_063125313.1 complement C1q tumor necrosis factor-related protein 1 isoform X2
XM_006247801.5 → XP_006247863.1 complement C1q tumor necrosis factor-related protein 1 isoform X1

See identical proteins and their annotated locations for XP_006247863.1

UniProtKB/Swiss-Prot

Q5XIG2

UniProtKB/TrEMBL

A0A0G2JXS9, A6HL59

Conserved Domains (2) summary

pfam00386
Location:147 → 275

C1q; C1q domain

pfam01391
Location:98 → 138

Collagen; Collagen triple helix repeat (20 copies)
XM_006247800.5 → XP_006247862.2 complement C1q tumor necrosis factor-related protein 1 isoform X1

UniProtKB/Swiss-Prot

Q5XIG2

UniProtKB/TrEMBL

A6HL59