Marchf7 membrane associated ring-CH-type finger 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Marchf7provided by RGD
Official Full Name: membrane associated ring-CH-type finger 7provided by RGD
Primary source: RGD:1308993
See related: Ensembl:ENSRNOG00000006241 AllianceGenome:RGD:1308993
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Axot; March7
Summary: Predicted to enable MDM2/MDM4 family protein binding activity; ubiquitin binding activity; and ubiquitin conjugating enzyme binding activity. Predicted to be involved in several processes, including negative regulation of signal transduction by p53 class mediator; protein ubiquitination; and regulation of cellular protein metabolic process. Predicted to act upstream of or within negative regulation of T cell proliferation and regulation of tolerance induction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in nucleus. Orthologous to human MARCHF7 (membrane associated ring-CH-type finger 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 285.9), Spleen (RPKM 237.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (65090640..65128768)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (44680229..44720172)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (46284961..46325230)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that MARCH7 is involved in spermiogenesis by regulating the structural and functional integrity of the head and tail of developing spermatids.
Title: MARCH7 E3 ubiquitin ligase is highly expressed in developing spermatids of rats and its possible involvement in head and tail formation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MDM2/MDM4 family protein binding	IEA Inferred from Electronic Annotation more info
enables MDM2/MDM4 family protein binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of tolerance induction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of tolerance induction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MARCHF7

Names: E3 ubiquitin-protein ligase MARCH7; MARCH-VII; RING-type E3 ubiquitin transferase MARCH7; RING-type E3 ubiquitin transferase MARCHF7; axotrophin; membrane-associated RING finger protein 7; membrane-associated RING-CH protein VII; membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase

NP_001012087.1

EC 2.3.2.27

XP_038960759.1

EC 2.3.2.27

XP_038960760.1

EC 2.3.2.27

XP_038960761.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012087.1 → NP_001012087.1 E3 ubiquitin-protein ligase MARCHF7

See identical proteins and their annotated locations for NP_001012087.1

Status: PROVISIONAL

Source sequence(s)

BC083842

UniProtKB/Swiss-Prot

Q5XI50

UniProtKB/TrEMBL

A0A8I6GH47, A6JF76

Conserved Domains (1) summary

cd16812
Location:550 → 611

RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

65090640..65128768

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104833.2 → XP_038960761.1 E3 ubiquitin-protein ligase MARCHF7 isoform X3

UniProtKB/TrEMBL

A0A8I6GH47

Conserved Domains (1) summary

cd16812
Location:564 → 625

RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)
XM_039104832.2 → XP_038960760.1 E3 ubiquitin-protein ligase MARCHF7 isoform X2

UniProtKB/TrEMBL

A0A8I6GH47

Conserved Domains (1) summary

cd16812
Location:564 → 625

RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)
XM_039104831.2 → XP_038960759.1 E3 ubiquitin-protein ligase MARCHF7 isoform X1

UniProtKB/TrEMBL

A0A8L2Q3F2, A6JF75

Conserved Domains (1) summary

cd16812
Location:564 → 625

RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)