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    Fgd6 FYVE, RhoGEF and PH domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500824, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Fgd6provided by RGD
    Official Full Name
    FYVE, RhoGEF and PH domain containing 6provided by RGD
    Primary source
    RGD:1565609
    See related
    Ensembl:ENSRNOG00000054515 AllianceGenome:RGD:1565609
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565609
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be involved in regulation of GTPase activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human FGD6 (FYVE, RhoGEF and PH domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 68.0), Lung (RPKM 62.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fgd6 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30484600..30599898)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28597609..28712908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (34951878..35063006)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093556 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene microRNA 331 Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FYVE, RhoGEF and PH domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137645.1 → NP_001131117.1  FYVE, RhoGEF and PH domain-containing protein 6

      See identical proteins and their annotated locations for NP_001131117.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/TrEMBL
      A0A0G2K7L6, A0A8I6G5H4, A6IG06
      Related
      ENSRNOP00000081090.1, ENSRNOT00000101771.1
      Conserved Domains (5) summary
      cd13237
      Location:1312 → 1400
      PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
      cd15793
      Location:1054 → 1176
      PH1_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 6, N-terminal Pleckstrin Homology (PH) domain
      cd15743
      Location:1193 → 1253
      FYVE_FGD6; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) and similar proteins
      pfam00169
      Location:1311 → 1402
      PH; PH domain
      pfam00621
      Location:852 → 1036
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      30484600..30599898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264098.1 → XP_063120168.1  FYVE, RhoGEF and PH domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AU60

    2. XM_039079738.2 → XP_038935666.2  FYVE, RhoGEF and PH domain-containing protein 6 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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