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    Pilra paired immunoglobin-like type 2 receptor alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910669, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Pilraprovided by RGD
    Official Full Name
    paired immunoglobin-like type 2 receptor alphaprovided by RGD
    Primary source
    RGD:6497409
    See related
    Ensembl:ENSRNOG00000062779 AllianceGenome:RGD:6497409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562847
    Summary
    Predicted to enable MHC class I protein binding activity. Predicted to be integral component of membrane. Orthologous to human PILRA (paired immunoglobin like type 2 receptor alpha) and PILRB (paired immunoglobin like type 2 receptor beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 314.2), Lung (RPKM 130.9) and 8 other tissues See more
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    Genomic context

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    Location:
    12q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (23452626..23464772)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17787169..17798149)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (21678550..21689821)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene RAP1B, member of RAS oncogene family, pseudogene 2 Neighboring gene paired immunoglobin like type 2 receptor beta 2 Neighboring gene zinc finger CW-type and PWWP domain containing 1-like 1 Neighboring gene paired immunoglobin-like type 2 receptor beta 1 like 3 Neighboring gene vomeronasal 2 receptor, pseudogene 104

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. Fournier N, et al. J Immunol, 2000 Aug 1. PMID 10903717
    2. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC class I protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    paired immunoglobin-like type 2 receptor alpha
    Names
    paired immunoglobulin-like type 2 receptor alpha
    paired immunoglobulin-like type 2 receptor alpha-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405389.1 → NP_001392318.1  paired immunoglobin-like type 2 receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      23452626..23464772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769107.4 → XP_008767329.3  paired immunoglobin-like type 2 receptor alpha isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADV0
      Related
      ENSRNOP00000091096.1
      Conserved Domains (2) summary
      cd00096
      Location:28 → 32
      Ig; Ig strand A [structural motif]
      cl11960
      Location:28 → 144
      Ig; Immunoglobulin domain

    2. XM_017598607.3 → XP_017454096.2  paired immunoglobin-like type 2 receptor alpha isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADV0, A0A8I6B5H6
      Related
      ENSRNOP00000097229.1
      Conserved Domains (2) summary
      cd00096
      Location:25 → 29
      Ig; Ig strand A [structural motif]
      cl11960
      Location:25 → 141
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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