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    Timm13 translocase of inner mitochondrial membrane 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252928, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Timm13provided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 13provided by RGD
    Primary source
    RGD:628845
    See related
    AllianceGenome:RGD:628845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Located in mitochondrion. Orthologous to human TIMM13 (translocase of inner mitochondrial membrane 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 382.9), Heart (RPKM 299.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9459490..9460849)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8809069..8810172)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11677340..11678443)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene growth arrest and DNA-damage-inducible, beta Neighboring gene uncharacterized LOC134479806 Neighboring gene lamin B2 Neighboring gene transmembrane serine protease 9 Neighboring gene uncharacterized LOC120093773 Neighboring gene signal peptide peptidase-like 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex. Roesch K, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875042
    2. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
    3. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
    4. Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Wang Z, et al. Dev Cell, 2014 Apr 28. PMID 24746669, Free PMC Article
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim13
    Names
    translocase of inner mitochondrial membrane 13 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145781.2 → NP_665724.1  mitochondrial import inner membrane translocase subunit Tim13

      See identical proteins and their annotated locations for NP_665724.1

      Status: VALIDATED

      Source sequence(s)
      AF144701, JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P62076
      Conserved Domains (1) summary
      pfam02953
      Location:24 → 84
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9459490..9460849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263024.1 → XP_063119094.1  mitochondrial import inner membrane translocase subunit Tim13 isoform X1

      UniProtKB/Swiss-Prot
      P62076
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62076.1 GenPept UniProtKB/Swiss-Prot:P62076

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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