CRHBP corticotropin releasing hormone binding protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: CRHBPprovided by HGNC
Official Full Name: corticotropin releasing hormone binding proteinprovided by HGNC
Primary source: HGNC:HGNC:2356
See related: Ensembl:ENSG00000145708 MIM:122559; AllianceGenome:HGNC:2356
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRFBP; CRF-BP
Summary: Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver (RPKM 36.1), kidney (RPKM 16.1) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q13.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (76953045..76981159)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (77434877..77462968)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (76248870..76265296)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease.
Title: Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease.
Integrative analysis reveals CRHBP inhibits renal cell carcinoma progression by regulating inflammation and apoptosis.
Title: Integrative analysis reveals CRHBP inhibits renal cell carcinoma progression by regulating inflammation and apoptosis.
The GCAG Haplotype of the CRHBP Gene May Decrease the Risk for Robbery Behavior Among the Han Chinese.
Title: The GCAG Haplotype of the CRHBP Gene May Decrease the Risk for Robbery Behavior Among the Han Chinese.
[Analysis of Correlation between Gene Polymorphisms of CRHBP in Yunnan Han Population and Schizophrenia and Aggressive Behavior].
Title: [Analysis of Correlation between Gene Polymorphisms of CRHBP in Yunnan Han Population and Schizophrenia and Aggressive Behavior].
Reduction in cocaine abuse among methadone maintenance treatment patients may be mediated by a genetic effect in a stress-related gene (CRHBP SNP rs1500 minor C allele).
Title: Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction.
found no differences in genotype distributions between heroin-dependent subjects and controls. However, identified a prominent interaction of one variant of the CRHBP gene predicting the risk of heroin relapse in the chronically stressed subjects.
Title: Association between stress pathway gene (CRHR1⧹CRHBP) polymorphisms and heroin dependence.
A measure of stressful life events was significantly predictive of alcohol use/misuse. In addition, this association was significantly dependent upon the number of putative risk variants at rs1715749, a single-nucleotide polymorphism (SNP) in CRHBP.
Title: Genes involved in stress response and alcohol use among high-risk African American youth.
We describe for the first time tumor specific epigenetic silencing of CRHBP and statistical association with aggressive tumors thus suggesting the CRH system to contribute to the development of kidney cancer.
Title: Tumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and Metastasis.
Genetic polymorphism rs7718461 in the CRHBP gene showed significant association with overall pain severity during the year after motor vehicle collision.
Title: CRHBP polymorphisms predict chronic pain development following motor vehicle collision.
These results suggest that the CRH and CRH-BP genes have no direct effect on Irritable bowel syndrome status.
Title: Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N27552 (e-PCR)
- UniSTS:65599

D5S2443 (e-PCR)
- UniSTS:66662

SHGC-36451 (e-PCR)
- UniSTS:22390

STS-X58022 (e-PCR)
- UniSTS:42888

RH75968 (e-PCR)
- UniSTS:86927

CRHBP (e-PCR)
- UniSTS:510379

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables corticotropin-releasing hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables corticotropin-releasing hormone binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cocaine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to estradiol stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to gonadotropin-releasing hormone	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to potassium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in female pregnancy	IDA Inferred from Direct Assay more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in learning or memory	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of corticotropin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of corticotropin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of corticotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of corticotropin-releasing hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulated exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of NMDA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of corticotropin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in synaptic transmission, dopaminergic	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in dense core granule	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in multivesicular body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in secondary lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in varicosity	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: corticotropin-releasing factor-binding protein

Names: CRF-binding protein; CRH-BP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.