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    Znrf1 zinc and ring finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690769, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Znrf1provided by RGD
    Official Full Name
    zinc and ring finger 1provided by RGD
    Primary source
    RGD:1592195
    See related
    Ensembl:ENSRNOG00000019028 AllianceGenome:RGD:1592195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in cytosol; endosome; and membrane. Orthologous to human ZNRF1 (zinc and ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 174.1), Muscle (RPKM 172.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Znrf1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56403816..56490901)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39496414..39581600)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43750205..43834962)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 59 Neighboring gene 60S ribosomal protein L29-like Neighboring gene uncharacterized LOC120098630 Neighboring gene uncharacterized LOC134483371 Neighboring gene lactate dehydrogenase D Neighboring gene zinc finger protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Wakatsuki S, et al. Nat Cell Biol, 2011 Nov 6. PMID 22057101
    2. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. Hoxhaj G, et al. J Cell Sci, 2012 Oct 1. PMID 22797923, Free PMC Article
    3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of autophagosome-lysosome fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ZNRF1
    Names
    zinc and ring finger 1, E3 ubiquitin protein ligase
    NP_001388008.1
    NP_001388009.1
    XP_006255712.1
    XP_006255713.1
    XP_006255714.1
    XP_038954193.1
    XP_038954194.1
    XP_038954195.1
    XP_038954196.1
    XP_063134365.1
    XP_063134366.1
    XP_063134367.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401079.1 → NP_001388008.1  E3 ubiquitin-protein ligase ZNRF1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZ93, D3ZIQ9

    2. NM_001401080.1 → NP_001388009.1  E3 ubiquitin-protein ligase ZNRF1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZ93, D3ZIQ9
      Related
      ENSRNOP00000025716.3, ENSRNOT00000025716.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      56403816..56490901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278295.1 → XP_063134365.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUZ1

    2. XM_006255650.4 → XP_006255712.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      See identical proteins and their annotated locations for XP_006255712.1

      UniProtKB/TrEMBL
      A0A8I5ZUZ1
      Conserved Domains (1) summary
      cd16694
      Location:216 → 261
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    3. XM_006255652.4 → XP_006255714.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      See identical proteins and their annotated locations for XP_006255714.1

      UniProtKB/TrEMBL
      A0A8I5ZUZ1
      Conserved Domains (1) summary
      cd16694
      Location:216 → 261
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    4. XM_006255651.4 → XP_006255713.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      See identical proteins and their annotated locations for XP_006255713.1

      UniProtKB/TrEMBL
      A0A8I5ZUZ1
      Related
      ENSRNOP00000083192.1
      Conserved Domains (1) summary
      cd16694
      Location:216 → 261
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    5. XM_039098265.2 → XP_038954193.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

      UniProtKB/TrEMBL
      A6IZ93, D3ZIQ9
      Related
      ENSRNOP00000093092.1
      Conserved Domains (1) summary
      cd16694
      Location:182 → 227
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    6. XM_063278296.1 → XP_063134366.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

      UniProtKB/TrEMBL
      A6IZ93, D3ZIQ9

    7. XM_039098266.2 → XP_038954194.1  E3 ubiquitin-protein ligase ZNRF1 isoform X3

    8. XM_039098268.2 → XP_038954196.1  E3 ubiquitin-protein ligase ZNRF1 isoform X5

    9. XM_039098267.2 → XP_038954195.1  E3 ubiquitin-protein ligase ZNRF1 isoform X4

    10. XM_063278297.1 → XP_063134367.1  E3 ubiquitin-protein ligase ZNRF1 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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