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    sul-1 Putative extracellular sulfatase Sulf-1 homolog [ Caenorhabditis elegans ]

    Gene ID: 180619, updated on 11-Apr-2024

    Summary

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    Gene symbol
    sul-1
    Gene description
    Putative extracellular sulfatase Sulf-1 homolog
    Primary source
    WormBase:WBGene00006308
    Locus tag
    CELE_K09C4.8
    See related
    AllianceGenome:WB:WBGene00006308
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in Golgi stack; cell surface; and endoplasmic reticulum. Orthologous to human SULF1 (sulfatase 1) and SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See sul-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (3267294..3270906, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Fatty acid-binding protein homolog 2 Neighboring gene F-box domain-containing protein Neighboring gene Ovule protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of the heparan modification network in Caenorhabditis elegans. Townley RA, et al. J Biol Chem, 2011 May 13. PMID 21454666, Free PMC Article
    2. Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases. Devany J, et al. Nano Lett, 2018 Feb 14. PMID 29313356
    3. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate 6-O-sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative extracellular sulfatase Sulf-1 homolog
    NP_508560.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3267294..3270906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076159.4 → NP_508560.1  Putative extracellular sulfatase Sulf-1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508560.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21376
      Conserved Domains (3) summary
      COG3119
      Location:36 → 381
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16147
      Location:34 → 376
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:605 → 654
      ALP_like; alkaline phosphatases and sulfatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21376.1

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